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New Study to Show How Rheumatoid Arthritis Patients Rate Improvement Change

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www.ProHealth.com • August 3, 2004


U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH NIH News National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov/ FOR IMMEDIATE RELEASE Tuesday, August 3, 2004 CONTACT: Kelli Carrington carringk@mail.nih.gov

NEW STUDY TO SHOW HOW RHEUMATOID ARTHRITIS PATIENTS RATE IMPROVEMENT CHANGE

A new clinical study to determine how people with rheumatoid arthritis (RA) evaluate improvements in disease symptoms will be carried out by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Department of Health and Human Services' National Institutes of Health. The study will examine how much of an improvement in pain, stiffness, function and other symptoms is needed before patients consider the change important.

The "Clinically Important Changes in Rheumatoid Arthritis" study will recruit 300 people 18 years of age or older who have been diagnosed with RA. Researchers are particularly interested in patients who are currently being treated with prednisone, methotrexate, leflunomide, infliximab or etanercept. Patients will be evaluated twice at the NIH Clinical Center in Bethesda, Md.: once at the start of the study and again over a 1- to 4-month period. At each visit, patients will undergo assessments, including a physical exam, a grip strength test, a walking test and a blood test. They will complete a computer-based exercise, and answer written questionnaires. The questionnaires will ask patients to rate the importance of change in pain, morning stiffness, fatigue, joint swelling, functioning, worry, depression and overall impressions since the first visit.

Many people with RA complain about the daily joint pain that is associated with the disease. In addition, doctors have noted that patients have feelings of helplessness, depression and anxiety. These symptoms together can interfere with a person's ability to carry out normal daily activities. Generally, doctors evaluate patients' health and treatment based on measures such as the number of joints that are tender or swollen, morning stiffness, grip strength and pain severity. Less attention is given to whether treatment results are meaningful to patients.

The results of this study will give doctors a measure of the degree of improvements in symptoms and signs of arthritis that patients think are important. This will provide a target to be used in evaluating new treatments. Using these patient-based criteria, doctors will know if a new treatment has a high likelihood of being rated by patients as helpful or not.

Rheumatoid arthritis is an autoimmune disease that affects 2.1 million Americans, occurring two to three times more often in women than in men. RA typically affects many joints and is a chronic ongoing illness, requiring long periods of observation and management. It is characterized by inflammation of the membrane lining the joint, which causes pain, stiffness, warmth, redness and swelling. The inflamed joint lining, the synovium, can invade and damage bone and cartilage.

For additional information on the RA clinical trial, please contact: Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: (301) 594-9774 (local), 1-866-411-1010 (toll free) or e-mail at prpl@cc.nih.gov

The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the Department of Health and Human Services' National Institutes of Health, is to support research in the causes, treatment and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research and the dissemination of information on research progress in these diseases. For more information about NIAMS, call the information clearinghouse at (301) 495-4484 or (877) 22-NIAMS or visit the NIAMS Web site at http://www.niams.nih.gov.



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