ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

How Can You Benefit From Vitamin B12?

Drug can dramatically reduce weight of people with obesity

What Is Bitter Orange?

 
Print Page
Email Article

Proposed treatment for diabetes could have devastating side effects

  [ 85 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 24, 2003


New research, published in open access journal BMC Immunology, reveals that a prospective treatment for autoimmune diseases such as diabetes and multiple sclerosis can result in serious side effects in mice. The researchers from Stanford University found that 86% of the diabetic mice they treated with peptide immunotherapy died as a result.

In humans type 1 diabetes is a serious autoimmune disease caused by the destruction of insulin producing cells in the pancreas by the body's immune system. This leaves diabetics unable to regulate their blood sugar without injections of insulin and at greater risk of developing blindness, heart disease and nerve problems.

In an effort to treat type 1 diabetes small molecules, known as peptides, are being developed to mimic the cells that trigger the autoimmune response. The idea of this immunotherapy is to trick the body into tolerating the cells that it would otherwise attack by "training" the immune system to ignore the insulin producing cells instead of killing them.

Earlier work had shown peptides derived from a protein known as GAD 65, that is expressed in the insulin producing cells in the pancreas, could be used to reduce the incidence of diabetes in mice that are genetically programmed to develop diabetes (NOD mice). This approach was thought to work by inducing a form of "tolerance" and/or by inducing a type of immune response that can be associated with allergic reactions.

Rosetta Pedotti and Maija Sanna and their colleagues from Stanford University investigated whether the injection of relatively large amounts of GAD 65 peptides into NOD mice might be effective in inducing tolerance and whether it caused any side effects.

The researchers injected the GAD 65 peptides into the abdomen of NOD mice each week for 3 weeks. Unfortunately, the potential therapeutic benefits of this treatment could not be evaluated because of an unanticipated side effect of the treatment. When the researchers gave the mice one further injection with the GAD 65 peptide preparation, four weeks after the original 3 week course of treatment, all of these mice developed a severe allergic reaction causing 86% of them to die within 30 minutes. In contrast, mice that had not received any previous peptide injections showed no adverse reactions.

Peptide immunotherapies are currently being studied in Phase I and Phase II clinical trials for both type 1 diabetes and multiple sclerosis. In contrast to the devastating side effects seen in mice, only minor allergic reactions were observed in clinical trials on over 200 patients and these were limited to around 10 % of patients. The frequency of minor reactions is similar to that seen with approved peptide based drugs like Copaxone. These results have been published in peer-reviewed journals [for example, Kappos et al, Nature Medicine, Oct. 2000].

Peptide immunotherapy has the potential to improve the lives of people at risk from developing asthma or autoimmune diseases - from patients with type 1 diabetes to multiple sclerosis sufferers. But the safety of the treatment must be paramount. Pedotti, Sanna and colleagues recognise the potential of this therapy but stress that 'great care must be taken' when attempting to suppress any autoimmune diseases using peptide immunotherapy. These conclusions are strengthened by earlier work from the same researchers using mice that were induced to have symptoms of another autoimmune disease, an animal model of multiple sclerosis.

This article in freely available in the open access, peer reviewed journal, BMC Immunology (http://www.biomedcentral.com/bmcimmunol/)



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map