ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Target for New Lung Cancer Therapy Found in Embryonic Cell Pathway

  [ 25 votes ]   [ Discuss This Article ] • March 5, 2003

New work by researchers in the Kimmel Cancer Center at Johns Hopkins may allow them to halt the smoking-induced cellular events that lead to 99 percent of all small cell lung cancers (SCLC). The research is reported in the March 5, 2003, issue of Nature.

The researchers found that a primitive cellular pathway, called Sonic Hedgehog (named for the cartoon character and spiky hairs it develops on fruit flies) stays turned on long after it should be turned off in some lung cancers.

"We believe chronic injury to the lungs by cigarette smoking re-activates genes in the Hedgehog pathway to repair cell damage in the lining of the lungs. The ongoing and regular assault to the lungs by cigarettes causes the usually dormant pathway to be stuck in activation mode making too many new cells, ultimately resulting in cancer," says Neil Watkins, Ph.D., research associate at the Kimmel Cancer Center and lead author of the study.

The Sonic Hedgehog pathway has been well studied for its role in the development of mammalian embryonic cells, and more recently, for its relationship to cancer. Now, Kimmel Cancer Center investigators are testing drugs on mice, including one called cyclopamine, that block the Hedgehog pathway. Human clinical trials are not planned at this time and may be three to four years away.

The scientists analyzed tissue samples and tumor cell lines from SCLC and non-small cell lung cancer (NSCLC) patients. Of ten SCLC tissue samples studied, half showed activation of the Hedgehog pathway and increased expression of one of its targets called the Gli1 gene. They confirmed these findings by looking at SCLC cell lines in which five of seven lines examined showed similar activation of the Hedgehog pathway and Gli1 gene. Limited activation of the pathway was found in NSCLC.

"This study represents one of the first attempts to therapeutically manipulate this cell pathway, and it's a perfect example of how basic developmental science can have clinical implications in a relatively short period of time," says Stephen B. Baylin, M.D., Ludwig professor of oncology and director of research at the Kimmel Cancer Center.

Lung cancer is the leading cancer killer. Close to 172,000 cases are diagnosed each year. Unresponsive to standard therapy, SCLC is the most lethal form of lung cancer. It typically cannot be treated with surgery and though it initially responds to chemotherapy, most patients relapse. "As cigarette smoking persists among young people, we expect to be dealing with this disease for years to come. As a result, the search for potential new therapies are key to controlling this disease," says Watkins.

In addition to Watkins and Baylin, other Johns Hopkins participants in this research include David Berman, Scott G. Burkholder, Baolin Wang, and Philip Beachy.

The research was funded by the Flight Attendant Medical Research Institute and a National Cancer Institute lung cancer SPORE (Specialized Projects of Research Excellence).

Related Web Sites:

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map