ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

More evidence for calorie restriction’s longevity effect

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Research Provides Further Support for Lifelong Influences on Brain and Cognitive Health

  [ 47 votes ]   [ Discuss This Article ]
By 1999 Progress Report by the NIA/NIH • www.ProHealth.com • December 13, 1999


Although most studies on AD address changes in late midlife and old age, there is some evidence to suggest that susceptibility to age-related cognitive changes or AD may be related to variables from much earlier in life. One set of evidence comes from studies on epidemiology of AD. For example, a paper from the Nun Study correlated the complexity of nuns' writing styles in late teenage years with their risk of developing AD in later life (Snowdon et al., 1996), and several studies suggest that more education is a protective factor for AD. The idea of "brain reserve" suggests that the more healthy neurons and connections between them can be established when the brain is developing in the fetus and maintained in later stages of development, the more time it will take for the ravages of AD to be manifested clinically. Studies in rats show that exercise can increase the number of neurons in a specific region of the hippocampus, suggesting that behavior modifications can modify the structure of adult brain. Could this be one approach to alleviating age-related decline? Would an enriched environment in early life be protective in our later years?

Another potentially important factor in promoting optimum brain health in later years is diet, even in the fetus. Recent research from investigators at Boston University School of Medicine has shown that alterations in choline availability to pregnant rats at the time the fetal brain is developing result in lifelong behavioral changes (Blusztajn, 1998). Offspring from choline-supplemented mothers were more adept as adults at tasks that measured attention and memory compared to the control and choline-deficient experimental groups. This improvement in cognitive behavior was evident even when the rats became very old. Thus, prenatal choline availability and supplementation alleviated the age-related decline in memory function, suggesting that long-lasting brain structural and functional changes are induced by choline. Could these play a part in defending against the clinical expression of AD? The results of these studies played a key role in the April 1998 decision by the Food and Nutrition Board of the National Academy of Sciences to classify choline as an essential nutrient and to recommend specific adequate intake levels.

Other studies in rats and humans conducted by investigators at the New York University School of Medicine also suggest that diet can play a part in brain defenses against cognitive deficits with age and AD. For example, long-term feeding of rats with a diet supplemented with antioxidant-rich substances such as spinach, strawberries, or vitamin E retarded age-related declines in spatial memory (Joseph et al., 1998). Beginning at 6 months of age, the rats were fed standard lab diets supplemented with extracts of spinach or strawberries, vitamin E, or no supplement and were then compared at 15 months of age for spatial memory performance in the Morris Water Maze task. Those animals receiving diets supplemented with substances rich in antioxidants showed none of the age-related cognitive declines typically seen in this spatial memory task. Spinach supplementation was particularly beneficial to the animals. Each dietary supplement was effective in retarding the age-associated deficits in several measures of brain metabolism. Additionally, the same research team has shown that short-term dietary supplementation with substances rich in antioxidants may partly reverse both cognitive and motor deficits seen with normal aging. Old rats (19 months) were given a diet supplemented with extracts of spinach, strawberries, or blueberries, or no supplement and compared on performance on motor and spatial learning tasks. Results showed that deficits of both motor coordination and spatial memory were reversed in the animals supplemented with blueberry extracts (Joseph et al., 1999). Furthermore, all animals that received any of the three dietary supplements showed improvements in cellular functions involved in transmission of chemical signals in brain.

In humans there are epidemiologic studies showing a correlation between antioxidant supplementation and reduction of risk for AD. Vitamin E has been shown to retard several milestones of AD progression (Sano et al., 1997) and it and other antioxidants are currently being tested in several clinical trials for preventing age-related memory deficits and development of AD. Epidemiologic studies also implicate folate, which is also being tested in an add-on component to the NIA-funded Women's Antioxidant Cardiovascular Study clinical trial for age-related memory impairment . Only the results of this sort of clinical trial and further basic research will show whether there are beneficial effects of dietary supplements on aging and AD.

Source: National Institutes of Health; National Institute on Aging
1999 PROGRESS REPORT ON ALZHEIMER'S DISEASE



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Complete and Natural Menopause Relief Complete and Natural Menopause Relief

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map