ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Researchers identify differing risk factors contributing to Parkinson's Disease in men and women

  [ 154 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 19, 2003


ROCHESTER, Minn. -- New Mayo Clinic research provides evidence that environmental factors may play a greater role in the development of Parkinson's disease in men, while for women, hereditary factors may play a greater role. The findings, to be published in the journal Movement Disorders, will be available Wednesday for early viewing online at http://www.interscience.wiley.com/jpages/0885-3185/.

The investigators performed an innovative two-step statistical analysis to study Parkinson's disease risk factors. They found that complex interactions between common gene variants contribute to Parkinson's disease risk in women.

The researchers postulate that environmental exposures often are sufficient to lead to Parkinson's disease risk in men.

"For women, genetic predisposition may be more important because they are less exposed to environmental risk factors linked to Parkinson's disease in previous research. Also, estrogen may protect women's brains from the effects of these environmental factors," says Demetrius Maraganore, M.D., Mayo Clinic neurologist and one of the study authors.

The medical community has known for many years that the incidence of Parkinson's disease is lower in women than in men, but the exact reasons have remained a mystery. Now, Dr. Maraganore and colleagues at Mayo Clinic in Rochester, Minn., and Jacksonville, Fla., have proposed an explanation.

"The causes of Parkinson's disease differ between men and women," says Dr. Maraganore. "Traditionally, men have been out in the workforce becoming exposed to environmental risk factors such as pesticides and industrial chemicals or suffering head injuries.

By contrast, women have been less exposed to these factors and require a stronger genetic susceptibility to develop Parkinson's.

Furthermore, estrogen, the main sex hormone in women, reduces the risk of developing the disease.

"For a woman to get Parkinson's disease, she has to inherit certain gene variants," says Dr. Maraganore. Hormonal factors combined with more limited environmental exposure may help protect women from Parkinson's disease.

In this study, Mayo Clinic researchers discovered an interaction between common variants of two genes -- ubiquitin carboxy-terminal hydrolase L1 (UCHL1) and a-synuclein -- that leads to a significantly higher risk of Parkinson's disease than commonly occurs in the population. Rare mutations in these two genes as well as in a gene called "parkin" also have been shown to cause rare inherited forms of Parkinson's disease.

The Mayo Clinic researchers performed genetic tests on blood samples from 319 unrelated Parkinson's disease cases and 196 cases with no evidence of Parkinson's disease. These patients are all part of ongoing Mayo Clinic studies of the causes of Parkinson's disease led by Dr. Maraganore and his colleague, Walter Rocca, M.D., Mayo Clinic epidemiologist.

Following the genetic studies, the researchers conducted a unique statistical analysis. Step one involved an automated search (recursive partitioning) for possible genetic interactions from the data collected about the study participants' DNA. Following this search, the investigators conducted a test of the significance of the gene interactions discovered.

The Mayo Clinic researchers currently are conducting further studies to test their hypothesis that environmental factors play a greater role in Parkinson's in men, while genetic factors play a larger role in women.

Parkinson's disease is a progressive condition that causes a movement disorder including generalized slowness, tremulousness and immobility. It may develop when motor-control circuits deep in the brain become disordered as a result of selective-cell degeneration.

The National Institute of Environmental Health Sciences, the National Institute of Neurological Disorders and Stroke, and Mayo Foundation funded this study.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Complete and Natural Menopause Relief Complete and Natural Menopause Relief

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map