ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

FDA Approves Drug for Arthritis

  [ 15 votes ]   [ Discuss This Article ]
By News release • www.ProHealth.com • April 23, 2000


FDA has approved Celebrex (Celecoxib), a new product to treat rheumatoid arthritis and osteo-arthritis. Celebrex is an NSAID or non-steroidal anti-inflammatory drug that blocks production of prostaglandins (fatty acids that perform hormone-like functions) by inhibiting the enzyme cyclooxygenase-2 (Cox-2). The following may be used to respond to questions:

Arthritis affects millions of Americans -- more than three million with rheumatoid arthritis, and 16 million with osteoarthritis, the most common form of arthritis affecting the elderly. Both cause painful inflammation and joint deterioration.

Unlike other NSAIDS, Celebrex does not inhibit the enzyme cyclooxygenase-1 or COX-1. Inhibition of COX-1 is believed to contribute to some of the adverse effects of NSAIDS, including upper gastrointestinal ulcers. It is therefore hoped that Celebrex will have safety advantages compared to other NSAID products.

Additional studies and post-marketing experience will add substantially to the understanding of how the overall risks and benefits of Celebrex compare with those of other NSAID products.

Celebrex was found to be an effective arthritis treatment in placebo and active-controlled clinical trials that enrolled 2100 patients with rheumatoid arthritis and 4200 patients with osteoarthritis.

Celebrex was compared to other NSAID products in several of these clinical trials by using endoscopes (a device to examine organs of the gastrointestinal tract) to determine the incidence of stomach and upper intestinal ulcerations following the use of these products. These studies showed that patients taking Celebrex had a substantially lower risk of ulcers detected by endoscopy over the study period of 12 to 24 weeks compared to patients who took other NSAIDS.

However, NSAID products can cause a range of gastrointestinal problems, and patients with endoscopic ulcers may often recover without special treatment and without experiencing any serious symptoms or complications. Therefore, additional studies in many thousands of patients would be needed to see whether Celebrex actually causes fewer serious gastrointestinal complications than other NSAID products. Until such studies are done, the drug labeling for Celebrex will include the standard warning for doctors and their patients about the risks associated with all NSAIDS, including risks of GI ulceration, bleeding and perforation. The labeling advises patients taking these drugs to be alert for ulceration and bleeding that can occur with or without warning. Patients should promptly report signs and symptoms of gastrointestinal ulceration or bleeding, skin rash, unexplained weight gain, or swelling to their physicians.

In addition, Celebrex does not affect platelet aggregation (clumping) an important part of the blood clotting process. Many other NSAID products can interfere with this platelet function, which may increase the risk of bleeding complications in some patients. However, Celebrex does not appear to be different from other NSAIDS in its effects on the kidneys.

Celebrex is manufactured by Searle of Chicago, Illinois.

Source: The Food and Drug Administration



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
"It's Not Easy Being Green" - But It Is Healthy
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map