ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

 
Print Page
Email Article

VIOXX Approved for Osteoarthritis and Menstrual Pain

  [ 32 votes ]   [ Discuss This Article ]
By News Release • www.ProHealth.com • April 24, 2000


FDA has approved Vioxx (rofecoxib), a new drug for treatment of osteoarthritis, menstrual pain and for the management of acute pain in adults. Vioxx is a non-steroidal anti-inflammatory drug or NSAID, and is the second approved version in a class of drugs commonly referred to as a "Cox-2 inhibitor". (Celebrex, the first, was approved in December l998.) The following may be used to respond to questions.

NSAID drugs temporarily relieve pain by blocking the body's production of prostaglandins, chemicals which are believed to be associated with the pain and inflammation of injuries and immune reactions.

An enzyme called cyclo-oxygenase is needed for the production of prostaglandins. People have two such enzymes, called cyclo-oxygenase 1 (Cox 1) and cyclo-oxygenase-2 (Cox-2). Most NSAIDS inhibit both these enzymes, but Vioxx and other selective Cox-2 inhibitors do not inhibit cyclo-oxygenase-1. Based on what is known about the role of Cox-1 and Cox-2, it is hoped that NSAIDS that selectively inhibit Cox-2 will have a lower incidence of some side effects (particularly certain adverse effects on the gastrointestinal system such as ulcers and bleeding), while still providing effective treatment for conditions such as pain and osteoarthritis.

In clinical trials of about 3600 people, Vioxx was found to be an effective treatment for the signs and symptoms of osteoarthritis -- the most common form of arthritis -- which is also known as a degenerative joint disease and tends to affect older people. Vioxx was also found effective for management of acute pain in adults, in studies conducted in people with post-operative pain following dental extractions or post-operative pain following orthopedic surgery; and for the management of pain related to the menstrual cycle.

Vioxx was compared to ibuprofen (a commonly used NSAID) and to placebo in two clinical trials by using endoscopes (devices to examine the upper gastrointestinal tract) to determine the incidence of stomach and upper intestinal ulcerations following use of these products. Treatment with 25 to 50 mg of Vioxx daily was associated with a significantly lower percentage of patients with endoscopic gastroduodenal ulcers than treatment with ibuprofen 2400 mg daily.
However, NSAID products can cause a range of gastrointestinal problems; and patients with asymptomatic ulcers found with endoscopy often recover without special treatment and without experiencing any serious symptoms or complications. A few cases of serious gastrointestinal bleeding and one case of obstruction occurred among patients taking Vioxx in clinical studies. Additional studies in a larger population would be needed to see whether Vioxx actually causes fewer serious gastrointestinal complications than older NSAID products. Until such studies are done, the drug labeling for Vioxx will include a warning for doctors and their patients about the risks associated with all NSAIDS, including risks of GI ulceration, bleeding and perforation. Patients are advised to promptly report signs and symptoms of gastrointestinal ulceration or bleeding, skin rash, unexplained weight gain, or swelling to their physicians.

In addition, Vioxx does not affect the platelet aggregation (clumping), an important part of the blood clotting process. Many other NSAID products can interfere with this platelet function, which may increase the risk of bleeding complications in some patients. However, like other NSAIDS, Vioxx appears to have some potential for causing adverse effects on the kidney, particularly at higher doses.

Source: The Food and Drug Administration



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map