Sore, achy inflamed joints due to chronic conditions like fibromyalgia, chronic fatigue syndrome and arthritis, or strenuous physical labor, do more than slow you down. They make life downright miserable.
For years, anti-inflammatory medications offered the best relief. Of course, these come with potential and unwanted side effects. Today however, research into anti-inflammatory botanicals and their active ingredients suggests all-natural, side effect free relief has arrived.
Curcumin captured the attention of researchers years ago as one of nature's most potent anti-inflammatory substances. Despite its promise, measurable effects proved difficult to identify in tests with live subjects.
More recently, researchers have found it works as well as over-the-counter NSAIDs like ibuprofen. Plus, a new proprietary formula called Longvida® Curcumin by Verdure Sciences® designed to deliver 65 times more active curcumin into the blood stream has been tested in human trials and produced significant, measurable results, including the reduction of several key causes of inflammation linked to achy, painful joints.
Causes of Joint Inflammation
Inflamed joints cause pain in addition to making movement difficult. Here are some of the potential causes of joint inflammation.
Injury to the cartilage or lubricating layer, called the synovium, can occur as a result of trauma, physical exertion or simply repeated wear and tear. Damage to the tissue starts a response from the innate immune system, the body's natural response to physical injury. Cells around the injury flood the area with inflammatory molecules like Interleukin-6, Interleukin-8 and TNF-alpha, a protein that helps break down damaged tissue and dead cells. This immune response leads to the swelling that causes pain and stiffness.
While the exact causes of autoimmune response continue to be researched, this condition features the innate immune system attacking healthy tissue, leading to inflammation, swelling and pain.
Some research suggests certain anti-inflammatory medications taken to relieve aches and pains may actually contribute to long-term erosion of tissue in the joint and may be contraindicated for older patients and those with osteoarthritis.
Reduced blood flow to joints compared to other tissue complicates recovery. In cases of injury to joints from any cause, the inflammation that results limits oxygen and nutrients from reaching the area quickly. This means inflammation lasts longer. It also causes recovery to take longer too.
That's one of the reasons anti-inflammatory drugs worked so well and have been the go-to for so many years. They reduced inflammation. Lower levels of inflammation meant less pain. They also meant faster healing as oxygen, nutrients, and other vital immune system molecules could reach the injury easier.
Of course, beyond the research that suggests anti-inflammatory drugs may actually damage joints, they also have potential side effects like upset stomach, gas, headache, and a mild rash.
3 Benefits of Curcumin
Research indicates curcumin has big advantages. It lowers inflammation. It's safe. And it helps improve blood flow.
A study published in the Journal of Medicinal Food reviewed clinical trials studying the effectiveness of turmeric and curcumin. The authors concluded the trials "provide scientific evidence that supports the efficacy of turmeric extract" and recommended larger studies.
Another 2014 study published in Clinical Interventions in Aging looked at a curcumin supplement compared to ibuprofen. The study involved 367 knee osteoarthritis patients where 185 took the curcumin versus the others who took ibuprofen. Researchers found the curcumin performed as well as the ibuprofen without side effects.
A further review of eight additional clinical trials evaluated curcumin's performance against anti-inflammatory medicines. The study authors reported curcumin performed as well in each of the eight trials.
Finally, researchers report curcumin increased nitric oxide levels in middle-aged and older adults. Nitric oxide plays an integral role in the flexibility of blood vessels and maintaining a healthy blood pressure.
Each of these supports curcumin as an excellent alternative to common anti-inflammatory medicines. The only problem has been that to enjoy these results requires taking very large doses of curcumin.
Longvida® Curcumin Delivers Big Results in a Small Dose
The human body quickly breaks down curcumin. In supplement form, only a small amount ever makes it into the blood. An individual who takes 5 grams (5,000 mg) daily would get an active dose of less than 200 mg.
Longvida® Curcumin eliminates this problem. It uses a proprietary and cutting-edge absorption-promoting system called SLCP™ technology to deliver 65 times more active curcumin in a much smaller dose.
To prove Longvida could offer the benefits without being quickly excreted from the body, University of North Texas researchers performed a clinical trial to evaluate its effect on inflammation. To measure inflammation, they tracked the inflammatory markers TNF-α, IL-8 and IL-6 in participants after performing high intensity exercise as a means to induce inflammation.
The day after the exercise, levels of TNF-α were 25% lower in participants who took Longvida® Curcumin. Levels of IL-8 fell 21% on the first day and remained 18% lower than the control group on day two. The study authors noted the presence of IL-6 came in lower than the control group at a significant level.
Researchers also noted levels of inflammation remained low in the test group for several days after the injury, even after supplementation had ended.
Added Benefits of Longvida® Curcumin
Research using Longvida® Curcumin suggests the reduction of the inflammatory molecules may provide wider support for overall health.
A study completed by researchers at Ohio State University reported Longvida -
Lowered triglyceride levels
Reduced levels of a molecule linked to cardiovascular disease
Supported liver health
The results of this study proved unique in that the tests were performed on healthy individuals, demonstrating positive effects regardless of current state of health.
Other benefits have been attributed to curcumin supplementation. These include antioxidant effects, improved digestive health, stable blood sugar levels as well as support for brain health and mood.
Who Is Likely to See the Greatest Benefits of Longvida® Curcumin
As demonstrated by the research, anyone of any age who experiences inflammation may benefit from this proprietary supplement. Those who suffer from chronic sore, achy joints may experience reduced inflammation with daily supplementation.
How to Get the Most from Longvida Curcumin
Take 1 to 2 capsules daily as a dietary supplement or as recommended by your doctor. Studies report results after 30 days of daily use, with some experiencing results within as little as one hour.
Anyone taking prednisone or any steroidal anti-inflammatory should not take Longvida Curcumin or any turmeric supplement. Avoid also if you have a biliary tract obstruction. Do not take if pregnant or breast-feeding. It is always recommended to speak with a physician or healthcare provider prior to starting any new diet, exercise or supplement.
Research shows Longvida® Curcumin reduces inflammatory markers associated with joint aches and pains. Since pain occurs in joints as a result of swelling, these results show promise as a way to help individuals suffering from many chronic conditions like fibromyalgia and chronic fatigue syndrome. In addition to relief for joint pain, Longvida® has demonstrated benefits for healthy individuals. Plus, previous studies have shown curcumin to be as effective as anti-inflammatory drugs. This suggests a supplement like Longvida may offer anti-inflammatory relief without undesired side effects.
ii Huskisson EC1
, Berry H
, Gishen P
, Jubb RW
, Whitehead J
. Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis. J Rheumatol.
1995 Oct;22(10):1941-6. https://www.ncbi.nlm.nih.gov/pubmed/8991995
Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food
. 2016;19(8):717-729. doi:10.1089/jmf.2016.3705. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/
iv Kuptniratsaikul V1
, Dajpratham P1
, Taechaarpornkul W2
, Buntragulpoontawee M3
, Lukkanapichonchut P4
, Chootip C5
, Saengsuwan J6
, Tantayakom K7
, Laongpech S8
.Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging.
2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535. eCollection 2014. https://www.ncbi.nlm.nih.gov/pubmed/24672232
v Perkins K1
, Sahy W1
, Beckett RD2
. Efficacy of Curcuma for Treatment of Osteoarthritis. J Evid Based Complementary Altern Med.
2017 Jan;22(1):156-165. Epub 2016 Mar 14. https://www.ncbi.nlm.nih.gov/pubmed/26976085
J. R. Santos-Parker1
, T.R. Strahler1
, C.J. Bassett1
, M.B. Chonchol2
, D.R. Seals. Biomarkers of aging and age-associated disease curcumin supplementation improves vascular endothelial function in middle-aged and older adults. The Gerontologist (2015) 55 (Suppl 2): 195. doi: 10.1093/geront/gnv554.01. http://gerontologist.oxfordjournals.org/content/55/Suppl_2/195.2.full
McFarlin, Brian K., et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clinical 5 (2016) 72–78. Available online 18 February 2016.
ix DiSilvestro RA1
, Joseph E
, Zhao S
, Bomser J
. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J.
2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.
x Cox KH1
, Pipingas A1
, Scholey AB2
. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol.
2015 May;29(5):642-51. doi: 10.1177/0269881114552744. Epub 2014 Oct 2.