Molecular hydrogen is one of “the most exciting breakthroughs in medicine in the last 100 years.” – Dr. Tony O'Donnell
Hydrogen is the smallest, oldest and most abundant element in the universe. Yet for centuries its therapeutic potential was largely ignored by the medical profession. What finally piqued their interest was an article published in Nature Medicine
in 2007, which showed the selective antioxidant properties and anti-apoptotic (anti-cell death) activities of molecular hydrogen.
Prior to this 2007 article, only 50 articles were published regarding the medical use of hydrogen gas. However, in the 10 years since then, there have been more than 500 articles published on the subject of molecular hydrogen. These studies suggest that “hydrogen has therapeutic potential in over 170 different human and animal disease models, and in essentially every organ of the human body.”[3,4]
Some of the amazing benefits of molecular hydrogen demonstrated by researchers in these studies include its ability to:
Penetrate the mitochondria to reduce oxidative stress.
Help the body fight chronic inflammation.
Boost energy, mental clarity and focus.
Encourage proper circulation and restful sleep.
Penetrate the blood-brain barrier to support cognitive function.
Support glucose homeostasis (weight management).
Suppress lactic acid build-up during exercise.
Stabilize cholesterol levels.
Provide anti-allergy effects.
Because molecular hydrogen is so small, it is able to pass through the blood-brain barrier and diffuse deep into cells, even entering the mitochondria. This ability allows this tiny but mighty molecule to work its magic on tissues and organs throughout the body.
How Molecular Hydrogen Works
One important way molecular hydrogen works is through its antioxidant effects. Antioxidants are substances that reduce the damage caused by free radicals (molecules that cause damage to cells, proteins and DNA and are associated with most human disease). Some of the best-known antioxidants include vitamins C and E and beta-carotene.
What makes molecular hydrogen different than other antioxidants is that it is a selective free-radical scavenger
. Contrary to what many think, not all free radicals are bad. Some free radicals are an important part of the REDOX (reduction and oxidation) signaling pathway. They act as triggers, causing the antioxidant mechanisms in our bodies to function properly.
While most antioxidants attack all types of free radicals, molecular hydrogen neutralizes only the most harmful and toxic free radicals (hydroxyl radicals), leaving the beneficial, performance-enhancing ones, like nitric oxide, superoxide and hydrogen peroxide, alone. In addition to its neutralizing effects, hydrogen has also been found to actually reduce the formation of some harmful free radicals.
Beyond just scavenging for free-radicals, studies have shown that molecular hydrogen is able to down-regulate pro-inflammatory cytokines and reduce the effect of other inflammatory mediators. It has also been found to have a positive effect on cell signaling, cell metabolism, gene expression and glutathione production. It is these various cell-modulating properties of hydrogen that help bring about its anti-inflammatory, anti-allergy and anti-obesity effects.[6.7]
How Molecular Hydrogen Is Administered
There are several ways to administer molecular hydrogen. In the past, the primary means were by the inhalation of hydrogen gas or through an intravenous injection of hydrogen-rich saline. But both of those methods are expensive and require medical supervision.
A much simpler and more cost-effective solution is to drink molecular hydrogen-infused water.
ProHealth is excited to be able to offer AquaH2 – a hydrogen-rich effervescent tablet you can simply dissolve in a bottle of water or other non-carbonated beverage. The result is the most concentrated molecular hydrogen-infused water available.
How to Use AquaH2
The most effective way to use AquaH2:
Drop one tablet into a bottle of water or other water-based beverage (between 8 oz and 16.9 oz).
Add enough water to fill the bottle to the brim.
Replace the cap and wait approximately 10 – 15 minutes for the tablet to dissolve.
Once you open the bottle again and begin to drink, try to finish it within 30 minutes.
Recommended use is twice a day.
AquaH2 has no taste, so it will not change the flavor of your water or other beverage.
Finally, one very important thing you should know about AquaH2 – it is safe and there are no known side effects. Unlike some other antioxidants that can become toxic if too much is ingested, any excess molecular hydrogen simply bonds with the oxygen in your body, turning into healthy, hydrating water.
1. Ohsawa, I., et al. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
. Nat Med
, 2007 13, 688-694.
2. Molecular Hydrogen: An emerging medical gas with therapeutic potential
. Molecular Hydrogen Foundation
. Retrieved 2/22/17.
3. Hydrogen: An emerging medical gas
. Molecular Hydrogen Foundation
. Retrieved 2/22/17.
4. Ichihara, M., et al., Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Med Gas Res
, 2015. 5: p. 12.
5. Sato, Y., et al., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice
. Biochem Biophys Res Commun
, 2008. 375(3): p. 346-350.
6. Kamimura, N., et al., Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice
7. Kamimura, N., et al., Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1 [alpha] to enhance fatty acid metabolism
. NPJ Aging and Mechanisms of Disease
, 2016. 2: p. 16008.