Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Best Herbs to Help With Insomnia

Meet the ProHealth Editors

Choline: Why You Should Eat Your Egg Yolks and Take Krill

 
Print Page
Email Article

Oxidative Stress

  [ 10 votes ]   [ Discuss This Article ]
By 1999 Progress Report by the NIA/NIH • www.ProHealth.com • December 13, 1999


Investigators continue to tease out the ways in which oxidative stress, which occurs as a result of over-production of free radicals, may play a role in neuronal damage and death. For example, one research team from Case Western Reserve University in Cleveland, Ohio, has attempted to distinguish the particular cell types in the brain that are most vulnerable to oxidative stress (Nunomura et al., 1999). They found that most of the oxidative damage to DNA and RNA in vulnerable neurons of AD involves RNA, not DNA. The several classes of RNA molecules, which are chemically similar to DNA, play essential roles in carrying genetic information from DNA in the nucleus to the outer portion of the cell, where the information serves as a blueprint for the manufacture of specific proteins. RNA also plays a critical role in the actual synthesis of the proteins. Oxidatively damaged RNA may interfere with these processes, and this may cause a malfunctioning protein to be made (one that has either gained a toxic function or lost a normal function). In turn, this could be one cause of the neuronal death that characterizes AD.

Other recent studies, conducted by scientists at the Sanders-Brown Center on Aging and the NIA-supported Alzheimer's Disease Research Center, have built on previous work detailing the direct evidence for free radical damage to neurons in AD. In one of these studies, scientists confirmed that certain types of free radicals, called 4-hydroxynonenal (HNE), which are toxic to neurons, are increased in several regions of the brain that have the most AD damage (Markesbery and Lovell, 1998). This study, in conjunction with cell culture studies and previous studies showing HNE elevation in cerebrospinal fluid of AD patients, suggests that HNE may also be important in the development of neuron damage in AD.

In a review of many studies on oxidative stress, the same team of investigators present evidence that the oxidative process damages brain fats, carbohydrates, proteins, and DNA, and also summarize the evidence for inflammatory processes in the brains of AD patients (Markesbery and Carney, 1999). They suggest that it is these two processes, working in concert, that contribute to the death of brain neurons and the consequent decline in mental function seen in AD patients.

Source:
National Institutes of Health
National Institute on Aging
1999 PROGRESS REPORT ON ALZHEIMER'S DISEASE



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map