ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Can Pomegranates Slow Aging?

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

What Benefits Can You Get From High-Quality Whey Protein?

 
Print Page
Email Article

Antioxidant treatment could halt neurodegeneration in early Parkinson's

  [ 2 votes ]   [ Discuss This Article ]
By Life Extension • www.ProHealth.com • September 20, 2017


Antioxidant treatment could halt neurodegeneration in early Parkinson's
Reprinted with the kind permission of Life Extension.

September 13 2017. An article appearing on September 7, 2017 in Science reports a potential benefit for antioxidant therapy against neurodegeneration in early Parkinson’s disease.

In human neurons derived from Parkinson’s disease patients, Dimitri Krainc and colleagues at Northwestern University identified a cascade that begins with mitochondrial oxidant stress leading to oxidized dopamine accumulation. This, in turn, results in a reduction in the activity of an enzyme known as lysosomal glucocerebrosidase, which weakens the function of the cells’ lysosomes:  organelles within the cell that contain over 60 different enzymes.  The cascade also results in the accumulation of alpha-synuclein, a protein that aggregates in the neurons of those with Parkinson’s disease. "The mitochondrial and lysosomal pathways are two critical pathways in disease development," explained Dr Krainc, who is the the Aaron Montgomery Ward Professor and chair of neurology at Northwestern University Feinberg School of Medicine. "Combined with the alpha-synuclein accumulation, this study links the major pathological features of Parkinson’s disease."

The researchers found that treatment with two different antioxidants, including N-acetylcysteine (NAC), interrupted the cascade. "One of the key strategies that worked in our experiments is to treat dopamine neurons early in the toxic cascade with specific antioxidants that improve mitochondrial oxidant stress and lower oxidized dopamine," Dr Krainc stated. "With this approach, we found that we can attenuate or prevent the downstream toxic effects in human dopaminergic neurons."

“Our long-term midbrain cultures demonstrated that early treatment with mitochondrial antioxidants reduced downstream accumulation of oxidized dopamine and alpha-synuclein, and rescued lysosomal dysfunction, highlighting the importance of early therapeutic intervention in the pathogenic cascade,” the authors conclude.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Safely Burn Away Body Fat Safely Burn Away Body Fat
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map