ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

Drug can dramatically reduce weight of people with obesity

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • October 31, 2017


Drug can dramatically reduce weight of people with obesity
Press Release: University of Leeds, October 23, 2017. A drug that targets the appetite control system in the brain could bring about significant weight loss in people with clinical obesity, according to new research.

On average, people lost 5kg (11lbs) over a 12 week period after receiving weekly doses of semaglutide, a compound currently being developed as a treatment for Diabetes.

Most of the weight loss came from a reduction in body fat, researchers at the University of Leeds found after reviewing its effectiveness. The drug reduced food cravings, with people choosing to eat smaller meals and decreasing their preferences for foods with a higher fat content. The study also added to the scientific understanding of how drug therapy can be used to tackle obesity. For the first time, scientists saw the benefit of very specific targeting of receptors or sensors that could affect multiple components of the brain's appetite control system.

John Blundell, Professor of Psycho-Biology at the University of Leeds and lead researcher, said: "What was striking was the potency of the drug's action. We saw results in 12 weeks which may take as long as six months with other anti-obesity medication.

"The drug reduced hunger but also cravings for food and the sensation of wanting to eat -- and these had previously been thought to stem from different parts of the brain."

The research has been published in the journal Diabetes, Obesity and Metabolism.

Semaglutide is a new drug being developed by the Danish pharmaceutical company Novo Nordisk as a treatment for diabetes.

Its chemical structure is very similar to the naturally-occurring hormone GLP-1 which is believed to act on the appetite control centre in the hypothalamus in the brain to reduce feelings of hunger.

Given the close similarity between semaglutide and the body's own appetite-control chemical, the study set out to examine whether the drug could also be used to tackle obesity by acting on the brain's appetite control receptors.

Professor Blundell said: "The potency of the drug is probably due to the action of the GLP-1 protein receptors on broad aspects of the appetite control system including hunger, craving and rewarding aspects of food."

In the study, the drug was given to 28 people with a body mass index (BMI) range of 30 to 45 kg/m2 -- meaning they were very overweight with a lot of body fat.
The participants were split in two groups -- half got semaglutide and the other half a placebo (dummy) substance for 12 weeks. They did not know what they were getting.

At the end of the 12 weeks, they were invited into a testing centre and offered a lunch and evening meal and told to consume as much as they needed to feel 'pleasantly full'. What they were eating was recorded, along with food preferences and their sensations of liking and wanting food. Body weight and body composition -- the percentage of body fat -- were also recorded.

They then repeated the process, with participants who got semaglutide this time getting the placebo and vice versa.

The results were then compared. The research team found that on average the daily energy intake, a measure of the amount of food consumed, was 24 per cent lower with semaglutide.

A further feature of the study was that measured energy expenditure from metabolic processes (the Resting Metabolic Rate) remained roughly the same throughout the experiment suggesting the weight loss could not be due to metabolism becoming more active. Consequently the fat loss produced by the drug could be attributed to better control over appetite.

Professor Blundell added: "A drug that reduces daily food intake by about a quarter with a substantial reduction in body fat will help some people to feel more in control of their lives and will help to prevent the onset of poor health that often arises from obesity" Semaglutide is in the advanced stages of development but is not yet on the market.

The study was funded by Novo Nordisk but carried out independently. The University of Leeds was asked to conduct the research because of its expertise in the science and investigation of appetite control.

 
Journal Reference: John Blundell, Graham Finlayson, Mads Axelsen, Anne Flint, Catherine Gibbons, Trine Kvist, Julie B. Hjerpsted. Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. Diabetes, Obesity and Metabolism, 2017; 19 (9): 1242 DOI: 10.1111/dom.12932



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map