ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Antibody Reduces Inflammation in Rheumatoid Arthritis

  [ 17 votes ]   [ Discuss This Article ]
By News Release • www.ProHealth.com • March 20, 2000


SUMMARY: Scientists have obtained data showing that an anti- properdin (a protein that participates in the destruction of bacteria) monoclonal antibody (MoAb) is effective at reducing inflammation in a rabbit model of immune complex deposition.The presence of immune complexes in the body has been suggested to lead to inflammatory conditions such as rheumatoid arthritis. Properdin is a protein of the complement alternative pathway, which along with the complement classical pathway serves as a host immune defense system. Inappropriate activation of complement has been shown to contribute to both acute and chronic disease pathologies, including those arising from rheumatoid arthritis. Taking MoAb could help reduce inflammation. CLEVELAND, March 20 /PRNewswire/ -- Gliatech Inc. announced today that company scientists have obtained data showing that an anti- properdin monoclonal antibody (MoAb) is effective at reducing inflammation in a rabbit model of immune complex deposition. The presence of immune complexes in the body has been suggested to lead to inflammatory conditions such as rheumatoid arthritis, lupus and nephritis.Properdin is a protein of the complement alternative pathway, which along with the complement classical pathway serves as a host immune defense system. Inappropriate activation of complement has been shown to contribute to both acute and chronic disease pathologies, including those arising from cardiopulmonary bypass surgery, myocardial infarction, stroke, rheumatoid arthritis and lupus. Gliatech has developed proprietary MoAbs to properdin that are potent inhibitors of the complement alternative pathway. By blocking the alternative pathway, the majority of the negative consequences of inappropriate complement activation can be attenuated while leaving certain aspects of the classical complement pathway available for normal host immune defense. The company has previously shown that its anti-properdin MoAbs effectively block complement activation in models of cardiopulmonary bypass surgery. In the present study, an anti-properdin MoAb was shown to dramatically reduce inflammation in rabbits that are induced to develop dermal immune complexes. This inflammation model mimics certain aspects of rheumatoid arthritis. The company recently announced that it has entered into a research collaboration with Abgenix Inc. to develop fully human anti-properdin MoAbs for use in clinical settings where inappropriate complement activation contributes to disease onset or progression. "This recent data further supports our premise that activation of the complement alternative pathway contributes to a variety of disease states," said Thomas O. Oesterling, Chairman and Chief Executive Officer of Gliatech Inc. "We are excited about the clinical and commercial potential of our anti- properdin monoclonal antibodies." Gliatech is a leader in the discovery and development of therapeutic products based on the properties of glial (comprising neuroglia – supporting tissue intermingled with elements of nervous tissue) cells. The Company applies its core glial research to developing innovative products for major unmet human health care needs. Current development initiatives are targeting products to improve surgical outcomes and to treat neurological disorders. Source: Gliatech Inc.,




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map