ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

AMA journal associates iron deficiency with hearing loss

Why the Mediterranean Diet Is so Successful

 
Print Page
Email Article

Arsenic in Drinking Water May be Linked to Cancer

  [ 156 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 7, 2003


Hanover, NH – Exposure to small amounts of arsenic in drinking water may inhibit expression of genes involved in a critical housekeeping function that enables cells to repair damaged DNA, Dartmouth Medical School researchers find. The process, known as DNA repair, is considered a major biological defense in the body's ability to fight cancer.

The study, published in the April issue the International Journal of Cancer, is the first to report diminished expression of DNA repair genes in cells taken directly from humans exposed to arsenic through their environment, according to lead author, Dr. Angeline Andrew, research assistant professor of community and family medicine. She and colleagues Dr. Margaret Karagas, professor of community and family medicine, and Dr. Joshua Hamilton, associate professor of pharmacology and toxicology, compared the arsenic exposure of individuals to expression of DNA repair genes isolated from samples of the same person's blood.

"We were primarily interested in uncovering the mechanism to explain how arsenic causes cancer," said Andrew, noting that arsenic is a well established carcinogen. "This study supports the hypothesis that arsenic may act as a co-carcinogen --not directly causing cancer, but allowing other substances, such as cigarette smoke or ultraviolet light, to cause mutations in DNA more effectively."

The study sheds light on the environmental factors that can increase cancer risk among Americans. The researchers, all faculty in Dartmouth's Center for Environmental Health Sciences and the Norris Cotton Cancer Center, used molecular tools to expand an ongoing study analyzing cancer risk in people exposed to arsenic through their well water.

Previous studies by Karagas and colleagues had established that toenails provide a good biomarker for arsenic exposure -- that is, the arsenic levels in an individual's toenails are well correlated to that person's internal dose of arsenic. When they compared arsenic exposure of individuals, as determined by the toenail clippings, with expression of DNA repair genes isolated from samples of the same person's blood, the researchers found an association between arsenic exposure and expression of certain DNA repair genes.

In people with elevated arsenic exposure, several important DNA repair genes were expressed at lower levels than in unexposed controls. The affected genes are those involved in nucleotide excision repair -- one of the body's primary defenses against DNA damage caused by environmental agents. Normally, these genes code for proteins that unwind DNA, cut the damaged DNA parts out, seal the repaired DNA back together, and help determine which cells are irreparable and must die.

"It is often difficult to establish patterns in human studies, due to inter-individual variation," said Andrew, "but our findings are consistent with the hypothesis that inhibition of DNA repair capacity is a potential mechanism for the co-carcinogenic activity of arsenic." She points out that the study involved a small number of individuals and a larger study is needed to verify the results.

Though arsenic has been known as a poison since ancient times, people in many regions of the world consume small amounts of arsenic every day in their drinking water. Exposure to these relatively small doses of arsenic has been linked to several kinds of cancer. This study is the first in a series of projects to determine the mechanisms responsible for the link between cancer and arsenic.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map