ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Link Made Between Dietary Folate, Genetic Instability and Bladder Cancer Risk

  [ 116 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 8, 2003


TORONTO - Individuals who are especially susceptible to genetic damage to their cells and who don't eat enough dietary folate are almost three times as likely to develop bladder cancer as are those who eat plenty of fruit and vegetables and who have efficient capacity to repair DNA damage, say researchers from The University of Texas M. D. Anderson Cancer Center.

Their study, published in the Proceedings for the 2003 Annual Meeting of the American Association for Cancer Research, clarifies a connection between lower intake of dietary folate and bladder cancer.

"The findings may have important implications for cancer prevention in susceptible populations," says Matthew Schabath, a predoctoral researcher working in the Department of Epidemiology.

He says that the ability to fix errant changes in DNA is of critical importance to maintain normal genetic structure, and this capability varies within the population. "A good prevention practice would be to limit exposure to DNA damaging agents (of which cigarette smoking is the most relevant for bladder cancer) and to eat foods containing folates and folic acid, such as fruits, vegetables, and fortified cereal grains, or take a daily supplement of folic acid, to reduce their risk of developing bladder cancer," he added.

Folic acid deficiency is one of the most common nutritional deficiencies in developed countries. Prior to the fortification of foods with folate, the deficiency was estimated to affect 10 percent of the U.S. population.

Folate itself is crucial to DNA synthesis and repair, Schabath says, so people who don't eat enough folate and who had inherited genetic instability are at much greater risk, he says.

Low intake of folate has already been associated with a number of cancers, including lung, cervical, colorectal, esophageal, brain, pancreatic and breast cancers, says Schabath.

In this study led by Xifeng Wu, M.D., Ph.D., in the Department of Epidemiology, Schabath and his research colleagues studied 272 patients newly diagnosed with bladder cancer and a control group of 257 healthy volunteers to compare folate intake from the diet and evidence of genetic instability. All of the participants were interviewed using a detailed food questionnaire and results of that survey showed that the control group had a much higher intake of folate than did patients -- a differencewhich was statistically different.

Researchers then drew blood samples to check which variants of four different DNA repair genes study participants had inherited. Three of the genes help eliminate chemicals that become incorporated into DNA because of external damage to a cell, such as by cigarette smoking, and the other gene repairs single errant base pair damage. They also measured the level of genetic instability in a laboratory culture test by "challenging" the blood samples with gamma radiation and with a carcinogenic metabolite associated with cigarette smoke to see if the cells could efficiently repair cell DNA damage.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map