ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Gladstone Researchers Find Method to Study Hidden HIV Reservoirs

  [ 614 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 16, 2003


Scientists are now one step closer to understanding how HIV hides in cells and rears its ugly head once patients stop taking combination drug therapy, which can suppress viral loads to undetectable levels. The phenomenon reflects the existence of hidden populations of latently infected cells. As a result, patients must remain on therapy for life.

Eradication of these cells could lead to a cure for HIV infection. However, researchers have been hampered by their inability to identify them.

Now Gladstone researchers have found a way to identify and study latently infected cells in the laboratory. Their work is published in the April 15 issue of the European Molecular Biology Organization Journal.

"The latent pool is considered to be the barrier to eradication," said senior author Eric Verdin, MD, senior investigator at the Gladstone Institute of Virology and Immunology and UCSF professor of medicine. "Our work is geared toward finding a way to obliterate this latent pool, which would take us closer to actually finding a cure for AIDS."

Through genetic engineering, the researchers constructed a recombinant HIV strain carrying a green fluorescent protein. Using this marker, they identified a small fraction of infected cells in which the virus was latent. These cells represented less than one percent of the infected population and had eluded purification until this study.

"Before, the study of latent infection was restricted to the analysis of rare cells circulating in the blood of infected patients. As an experimental model to dissect the molecular basis of latency, these cells were very limiting," Verdin said. "We now have a laboratory model that we can use to delve deeply into what is going on."

During infection, the HIV genome integrates into the host cell's DNA. Transcription of the viral genome leads to production of virus. The Gladstone researchers found that, in latently infected cells, the HIV genome is integrated into transcriptionally inactive regions of DNA called heterochromatin.

Verdin and his colleagues are now trying to identify drugs that can activate latent cells and cause them to produce virus. A preliminary screen identified a number of compounds that can reactivate latent HIV in the laboratory.

"Hopefully, we will be soon in a position to test some of these compounds in an animal model infected with a virus related to HIV. This will allow us to determine whether the "flushing" of latent pools is a viable therapeutic approach in HIV infection," Verdin said.


The other authors of the study are Albert A. Jordan, PhD, and Dwayne A. Bisgrove, PhD. Both are postdoctoral fellows at Gladstone.

The Gladstone Institute of Virology and Immunology is one of three research institutes at The J. David Gladstone Institutes, a private nonprofit biomedical research institution affiliated with UCSF. The institutes are named for a prominent real estate developer who died in 1971. His will created a testamentary trust that reflected his long-standing interest in medical education and research.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map