ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Rutgers Researcher Discovers Melanoma Causing Gene

  [ 15 votes ]   [ Discuss This Article ] • April 21, 2003

NEW BRUNSWICK/PISCATAWAY, N.J. -- Rutgers Associate Professor Suzie Chen has discovered a gene responsible for melanoma, the most aggressive form of malignant skin cancer. A paper describing the research by Chen and her colleagues at the National Human Genome Research Institute will be published online by Nature Genetics on April 21, and will appear subsequently in a print issue of the journal.

Melanoma may appear in places that never see sun, spread to other parts of the body and become lethal. This type of cancer is not generally responsive to chemotherapy. According to a report from the National Cancer Institute, in the United States the incidence rate of melanoma has more than doubled in the past 20 years.

Chen has been on the track of this gene since her 1995 arrival at Rutgers, The State University of New Jersey. Her research was conducted in the Susan Lehman Cullman Laboratory for Cancer Research at Rutgers' Ernest Mario School of Pharmacy.

"I did not set out to do a melanoma study," said Chen. "All my life I have been interested in cell transformation and differentiation. In this case, I was investigating how a fat cell becomes a fat cell when I observed that one of the mice in my experiment developed pigmented tumors. Upon further characterization, these tumors were confirmed to be melanoma.

"After many years of work, we identified a gene that was involved in these skin abnormalities and went on to prove that it indeed causes melanoma in the mouse system," said Chen.

Surprisingly, the gene is not a known oncogene – one known to cause cancer – but one whose normal functions are in the brain.

Chen explained that the expression of a given gene, whether it is turned on or off, or when, is tightly regulated by many factors. "It is only in a melanocyte skin cell when the expression of this particular gene is turned on that it leads to the development of melanoma," said Chen. "While in the brain, where it is expressed normally, its functions are associated with learning and memory."

Chen and her collaborators took the next step in this scientific investigation using human biopsy tissues with various stages of melanoma. In more than one third of these human samples, they detected signs of the same aberrant gene expression seen in the laboratory animals that had melanoma. This confirmed that the gene involved in melanoma development in the mice is also implicated in some human melanomas. While there are typically many paths leading to cancer development, this is a breakthrough in pinpointing one of them that occurs in both animals and humans.

"We hope to use this knowledge we've gained to investigate better ways of treating the disease. Early detection is key in treating melanoma, but malignant melanoma does not normally respond well to conventional chemotherapy," said Chen. "We need to find more effective ways to treat the disease. The biggest problem we have is our inability to target the tumor cells. Most of the treatments available today affect normal cells, as well. With our understanding of at least one genetic factor in melanoma, we may now have the ability to design a new, more specific drug to target that gene or the protein it expresses," she concluded.

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map