ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Protein interactions demonstrate that Alzheimer’s and Parkinson’s disease may share a common fiber

  [ 186 votes ]   [ Discuss This Article ] • April 24, 2003

Tau and alpha-synuclein proteins encourage each other to produce brain lesions

(Philadelphia, PA) – The amyloid lesions that cause Alzheimer’s and Parkinson’s disease are made of clumps of tangled proteins, but these clumps are composed of different protein subunits. Researchers at the University of Pennsylvania School of Medicine have discovered, however, that the tau proteins found in Alzheimer’s disease and the alpha (á)-synuclein proteins found in Parkinson’s disease can facilitate each other to form amyloid lesions in the laboratory.
Their findings, presented in this week’s issue of Science, provide insights into the mechanisms underlying both diseases and suggest that therapeutics developed for one disease might be efficacious for both.

“We are trying to understand the basic pathological overlap between the different amyloid lesions that cause Alzheimer’s and Parkinson’s, ” said Virginia M. -Y. Lee, PhD, professor in Penn’s Department of Pathology and Laboratory Medicine and Director of Penn’s Center for Neurodegenerative Disease Research (CNDR). “This fundamental relationship may explain why patients with one disease are more likely to exhibit signs of the other disease.”

The researchers showed that the á-synuclein proteins that form Lewy bodies in Parkinson’s disease can induce tau proteins to form the sort of fiber aggregates found in Alzheimer’s disease. Moreover, interactions between the tau and the á-synuclein proteins can dramatically induce the formation of fibrous clumps of both proteins.

“This newly uncovered interaction between these two proteins suggests that therapeutic agents created to directly or indirectly inhibit the formation of one form of amyloid lesion might be effective for treating other forms of amyloid lesions,” said Benoit Gaisson, PhD, lead author of the paper and researcher at the CNDR. “That is, a drug meant to keep Lewy bodies from forming to prevent Parkinson’s disease might also help prevent tau tangles from forming in Alzheimer’s disease.”

The two proteins, tau and á-synuclein are naturally abundant in the brain, but have distinct functions. Tau has a binding role in the structures of neurons, while á-synuclein is thought to be involved in regulating communications in the synapses between neurons.

The researchers knew that the smaller of the two proteins, á-synuclein, could bind to itself in homogenous clumps. The tau protein, meanwhile, is larger and it requires co-factors to aid overcoming a folding threshold. While the Penn researchers initially demonstrated that á-synuclein could aid tau into forming fibers in a test tube, the researchers also wanted to know if this also occurred in vivo. Using mouse models, they were able to demonstrate that á-synuclein polymerization alone is sufficient to induce the assembly of tau clumps in cells of the brain. Moreover, they were able to demonstrate that the same phenomenon occurs in a similar group of individuals with a known genetic abnormality in the ?-synuclein gene.

“After this initial step, we see a cycle begin to emerge,” said Gaisson. “Tau and á-synuclein work together to promote and propagate each other’s formation of fibrous clumps and, hence, the amyloid lesions that cause disease.”

Other scientists involved in the research paper described here include Mark S. Forman, Makoto Huguchi, Charles L. Graves, Paul T. Kotzbauer, and John Q. Trojanowski from Penn; and Lawrence I. Golbe from the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School.

Funding for this research was supported by the National Institutes on Aging and by a Pioneer Award from the Alzheimer’s Association.

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Safely Burn Away Body Fat Safely Burn Away Body Fat
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map