ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

 
Print Page
Email Article

New Understanding Into the Mechanics of Migraine

  [ 53 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 12, 2002




By Kathryn Senior


New insights into how migraine begins are revealed this week by US researchers, who have shown that cortical spreading depression (CSD), a wave of depolarisation that spreads across the cerebral cortex, activates afferent fibres with the trigeminal nerve. The CSD has long been associated with the visual disturbance--the aura--that many people with migraine report 20-30 min before a headache starts.

Hayrunnisa Bolay (Massachusetts General Hospital, Boston, MA, USA) and colleagues investigated the effects of an experimentally induced CSD in rats using laser speckle-contrast imaging. This technique generates two-dimensional maps of blood flow within the cerebral cortex, pial vessels, and middle meningeal artery. CSD was initiated using a pin-prick to the cortical surface and relative blood flow maps were generated at various time points. Blood flow in the middle meningeal artery was selectively increased, with a peak reached after 15 min. Further studies in rats with unilateral transection of the trigeminal branch that innervates the meninges revealed that this increased blood flow was dependent on trigeminal nerve stimulation. This stimulation leads also to plasma protein leakage within the dura mater via a neurokinin-1-receptor mediated mechanism (Nat Med 2002; 8: 136-42).

"This study provides the first experimental evidence that intense brain activity promotes reflex dilation of large extracerebral arteries", comments senior researcher Michael Moskowitz. "In this model, dilated blood vessels did not cause the headache pain but rather it developed in response to trigeminal brain stem reflexes stimulated by triggering events within brain."

The specific hypotheses proposed in the study are testable in people who have migraines, and Moskowitz predicts that further studies in humans may uncover novel mechanisms by which comorbidity events and "triggers" (eg, stress, depression, lack of sleep, and some drugs) influence susceptibility to migraine attacks.

Constantino Iadecola (Weill Medical Center of Cornell University, New York, NY, USA), author of an accompanying commentary (Nat Med 2002; 8: 110-11), says that this work also opens the way for new therapeutic approaches for migraine with aura. Moskowitz agrees but warns that "CSD probably comes and goes too quickly for drug treatments to be effective acutely". Nevertheless, this mechanism could provide an interesting therapeutic target for migraine prophylaxis, "especially if we understood how or why it begins, or how CSD activates the trigeminal nerve", says Moskowitz.

Iadecola points out that any CSD interventions may not help all migraine sufferers since most do not experience an aura. "The mechanisms of the headache might be different in cases with and without aura, a possibility hinted at by genetic studies", says Iadecola. "It may also be that the aura is not clinically evident because it involves 'silent' brain areas. Functional imaging studies might provide important clues on this complex problem."


Source: The Lancet



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map