ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Basic Aromatherapy to Help Balance and Calm

Tea drinkers have lower glaucoma risk

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Wonderful White Tea: A Drink Fit for an Emperor

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Acid Reflux May Respond Better to Foods Than Prescribed Pills

 
Print Page
Email Article

Study of Bacterial Enzyme Reveals One Key to Cancer Cell Survival

  [ 51 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 24, 2003


WINSTON-SALEM, N.C. – An enzyme that helps disease-causing bacteria withstand attacks by the body's natural defenses turns out to be a key to human cell survival and growth and may help explain why cancer cells can multiply unchecked.

Leslie B. Poole, Ph.D., of Wake Forest University Baptist Medical Center said the explanation begins with the way that bacteria -- such as one that causes food poisoning -- use the enzyme to combat hydrogen peroxide. Hydrogen peroxide, best known as hair bleach or as an antiseptic, is toxic to cells and is one weapon that the body's white blood cells release in an attempt to kill invaders.

Bacteria such as salmonella use the enzyme, called a peroxiredoxin, to inactivate the hydrogen peroxide coming from the white blood cells.

In the April 25th issue of Science, Poole, associate professor of biochemistry, and her colleagues at Oregon State University describe how the same group of peroxiredoxin enzymes work differently in people and other mammals. The enzyme becomes the biochemical switch that keeps the amount of hydrogen peroxide in the body low, but allows it to increase when it is used for intracellular signaling.

The body's cells respond to their environment by generating signals to communicate between one another and between molecules inside the cells, Poole said.

"Hydrogen peroxide is an effective signaling molecule because it is rapidly produced, is reactive and is easily controlled by antioxidant enzymes," Poole said. The complex signaling pathways occur in mammals but not in bacteria.

What determines whether hydrogen peroxide acts as a dangerous oxidant or as a signal? The investigators propose that the peroxiredoxin enzyme controls the floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels for signaling.

After studying the enzyme using Oregon State's single crystal X-ray diffractometer, Poole and her colleagues found that related peroxiredoxins have unique structures that have different shapes depending on whether they are used solely to prevent the flow of hydrogen peroxide or whether the hydrogen peroxide is also being used for signaling.

They propose that the enzyme ordinarily keeps the hydrogen peroxide in check, so that no signaling is produced. When the hydrogen peroxide is needed for signaling, an intracellular burst of hydrogen peroxide overwhelms the enzyme, switching it off and permitting the signal. When too much of the enzyme is present, the burst of hydrogen peroxide can't inactivate all of it, and the signal is blocked.

However, Poole said the bacterial peroxiredoxins -- like the ones in salmonella that she has studied -- "are resistant to this inactivation."

She explained, "Because the bacteria don't have the complex signaling pathways present in mammals, they don't need this ability to turn off the peroxiredoxin." So the enzyme is always available to eliminate hydrogen peroxide.

This discovery may shed light on human disease processes.

For example, Poole and her colleagues believe peroxiredoxin-regulated signaling may also be related to cancer. Ordinarily, abnormal cells in the body are programmed to die off, a process that scientists call apoptosis. In some cancer cells, apoptosis stops working, which means the cancer cells don't die off. The cancer cells may never get the signal to die because of the peroxiredoxin enzyme.

They found a correlation between this failure and too much peroxiredoxin, suggesting the two could be related.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map