ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

 
Print Page
Email Article

Brookhaven lab collaboration determines how aging affects brain chemistry

  [ Not Yet Rated ]   [ Discuss This Article ]
By Press Release • www.ProHealth.com • January 1, 2000


UPTON, NY - How does aging affect the brain? Researchers from the U.S. Department of Energy's Brookhaven National Laboratory, the State University of New York at Stony Brook and the University of Pennsylvania School of Medicine have found chemical changes in the brain that may underlie the cognitive deterioration associated with aging. The results of their experiment will be reported in the January 2000 issue of The American Journal of Psychiatry.
"In this study, we have shown that age-related loss of dopamine, the brain chemical associated with pleasure and reward, slows metabolism in regions of the brain that are related to cognition. This finding may be helpful in developing interventions for age-related cognitive decline," said Dr. Nora Volkow, Brookhaven's Associate Director for Life Sciences and the lead author of the study.

The researchers found that age is associated with a significant decline in dopamine D2 receptors - molecules that transmit signals that are associated with pleasure and reward in the brain. Approximately six percent of these receptors are lost with each decade of age, from 20 to 80 years. This decrease in dopamine with aging has been corroborated by other studies performed by Volkow and others. In the current investigation, for the first time, researchers discovered that when dopamine D2 receptors decreased, so did regional glucose metabolism in areas of the brain that are related to cognition.

In the group of healthy participants, glucose metabolism decreased with age in the frontal brain regions and in a part of the brain known as the anterior cingulate gyrus. Decreased glucose metabolism translates to decreased brain activity, or deterioration of brain function. The frontal brain region controls such functions as problem solving, the ability to think abstractly, and the ability to carry out multiple tasks simultaneously. The anterior cingulate gyrus is related to attention span, impulse control and mood.

The correlation between dopamine availability and brain metabolism remained significant after removing age effects in this investigation, which suggests that dopamine may influence brain metabolism regardless of age. (While dopamine declines with age in general, it is not always the case, and some younger people may have less dopamine than some older individuals.)
The research was carried out using an imaging technique known as positron emission tomography. The researchers measured dopamine D2 receptors and glucose metabolism in the brains of 37 healthy subjects, 24 to 86 years old. No participant took medication during the time of the study, and all participants were screened for psychoactive drug use.
This study was funded by the U.S. Department of Energy and the National Institute on Drug Abuse. It was carried out following guidelines set forth by the Institutional Review Board at Brookhaven National Laboratory, which regulates experiments on humans.

The U.S. Department of Energy's Brookhaven National Laboratory creates and operates major facilities available to university, industrial and government personnel for basic and applied research in the physical, biomedical and environmental sciences, and in selected energy technologies. The Laboratory is operated by Brookhaven Science Associates, a not-for-profit research management company, under contract with the U.S. Department of Energy.

Source: Press Release, January 1, 2000.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Live Without Anxiety or Stress Live Without Anxiety or Stress
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map