ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

Brookhaven lab collaboration determines how aging affects brain chemistry

  [ Not Yet Rated ]   [ Discuss This Article ]
By Press Release • • January 1, 2000

UPTON, NY - How does aging affect the brain? Researchers from the U.S. Department of Energy's Brookhaven National Laboratory, the State University of New York at Stony Brook and the University of Pennsylvania School of Medicine have found chemical changes in the brain that may underlie the cognitive deterioration associated with aging. The results of their experiment will be reported in the January 2000 issue of The American Journal of Psychiatry.
"In this study, we have shown that age-related loss of dopamine, the brain chemical associated with pleasure and reward, slows metabolism in regions of the brain that are related to cognition. This finding may be helpful in developing interventions for age-related cognitive decline," said Dr. Nora Volkow, Brookhaven's Associate Director for Life Sciences and the lead author of the study.

The researchers found that age is associated with a significant decline in dopamine D2 receptors - molecules that transmit signals that are associated with pleasure and reward in the brain. Approximately six percent of these receptors are lost with each decade of age, from 20 to 80 years. This decrease in dopamine with aging has been corroborated by other studies performed by Volkow and others. In the current investigation, for the first time, researchers discovered that when dopamine D2 receptors decreased, so did regional glucose metabolism in areas of the brain that are related to cognition.

In the group of healthy participants, glucose metabolism decreased with age in the frontal brain regions and in a part of the brain known as the anterior cingulate gyrus. Decreased glucose metabolism translates to decreased brain activity, or deterioration of brain function. The frontal brain region controls such functions as problem solving, the ability to think abstractly, and the ability to carry out multiple tasks simultaneously. The anterior cingulate gyrus is related to attention span, impulse control and mood.

The correlation between dopamine availability and brain metabolism remained significant after removing age effects in this investigation, which suggests that dopamine may influence brain metabolism regardless of age. (While dopamine declines with age in general, it is not always the case, and some younger people may have less dopamine than some older individuals.)
The research was carried out using an imaging technique known as positron emission tomography. The researchers measured dopamine D2 receptors and glucose metabolism in the brains of 37 healthy subjects, 24 to 86 years old. No participant took medication during the time of the study, and all participants were screened for psychoactive drug use.
This study was funded by the U.S. Department of Energy and the National Institute on Drug Abuse. It was carried out following guidelines set forth by the Institutional Review Board at Brookhaven National Laboratory, which regulates experiments on humans.

The U.S. Department of Energy's Brookhaven National Laboratory creates and operates major facilities available to university, industrial and government personnel for basic and applied research in the physical, biomedical and environmental sciences, and in selected energy technologies. The Laboratory is operated by Brookhaven Science Associates, a not-for-profit research management company, under contract with the U.S. Department of Energy.

Source: Press Release, January 1, 2000.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map