ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Protein fragment found to help improve chemotherapy

  [ 125 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 20, 2003


USC researchers find ways to improve effectiveness against tumors
Los Angeles, Calif., May 20--Researchers from the Keck School of Medicine of the University of Southern California have isolated a protein fragment derived from the cancer immunotherapy drug interleukin 2 (IL-2) that seems to enhance the uptake of chemotherapeutic agents into tumors.

In fact, says Alan Epstein, M.D., Ph.D., professor of pathology at the Keck School of Medicine, when this patented protein fragment is attached to a tumor-targeting antibody, it can prompt tumors to soak up more than 300 percent the normal amount of chemotherapy drugs. It does this, Epstein says, by making the tumor's blood vessel walls more "open" or permeable to the drugs. (Blood vessel walls are made of epithelial cells that are usually tightly joined together; when the junctions between those cells loosen up, it becomes easier for molecules to enter or leave the bloodstream.)

This work was described in a paper being published in the May 21, 2003 issue of the Journal of the National Cancer Institute.

The interleukins are part of a class of proteins called cytokines, which play a role in the human immune response. It's been hoped that interleukin 2 (IL-2) and its brethren might play a central role in cancer immunotherapy-battling cancer by revving up the immune system. Unfortunately, IL-2 can only be tolerated in small doses by the body. Taken at levels that would take advantage of its therapeutic value, it causes wide-spread edema and other problems due to blood vessel leakiness.

While seeking the cause of this leakiness, Epstein and his Keck School of Medicine colleagues isolated a stretch of 37 amino acids on the IL-2 protein; this sequence, he says, "is responsible for 100 percent of the vasopermeability." Dubbed PEP, for permeability-enhancing peptide, the molecule is now being commercially developed by Peregrine Pharmaceuticals of Tustin, Calif.

Having determined that PEP is indeed a permeability enhancer, Epstein and his colleagues took their exploration a step further: They transplanted mice with human tumor cells and pretreated them with monoclonal antibodies coupled with PEP.

When these mice and control mice were later injected with a radiolabeled tracer antibody or drug, there was a three to four fold increase in the amount of the antibody taken up by the tumors of the pretreated mice than those of the control mice.

"We've showed that you can use PEP to induce selective and reversible blood vessel permeability at the tumor site to get better drug uptake," says Epstein. "This may turn out to be a hugely important tool in cancer therapy."

The next step, he says, "is to try to get this product ready to test in human patients."



This work was supported by grants from the National Cancer Institute, Peregrine Pharmaceuticals, Inc. and Cancer Therapeutics Laboratories.

Alan L. Epstein, Myra Mizokami, Jiali Li, Peisheng Hu, Leslie A. Khawli, "Identification of a Protein Fragment of Interleukin 2 Responsible for Vasopermeability." Journal of the National Cancer Institute, Vol. 95, No. 10, May 21, 2003, pp. 741-749.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Vitamin D3 Extreme™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Safely Burn Away Body Fat Safely Burn Away Body Fat
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map