ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Virtual biopsy' - A new way to look at cancer

  [ 29 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 30, 2003


COLUMBUS, Ohio - Scientists are using new imaging technology to help them perform "virtual biopsies," – biological profiles of specific tumors that may help predict a patient's response to treatment and probability of long-term survival. This whole new realm of imaging is called functional MRI (magnetic resonance imaging), a process that offers insight into a tumor's character, not just its superficial structure.

Using functional MRI, Dr. Michael Knopp, a radiologist and a member of The Ohio State University Comprehensive Cancer Center's Experimental Therapeutics Program, is studying breast, prostate, pancreatic tumors and others to see if some of their particular biological quirks are related to response to treatment and survival.

Knopp says while X-rays can reveal information about a tumor's size and shape, that information alone is not enough to help physicians plan and tailor some of the newest treatments. "It's not what we see, but what we don't that may be more important."

What X-rays don't show, but what functional MRI does, says Knopp, includes biological processes like angiogenesis, or blood vessel growth surrounding a tumor. Using MRI and special contrast agents, Knopp is able to determine the permeability, or "leakiness" of the tumor's support system. Early studies suggest the "leakier" the vessels, the more likely a patient will respond to treatment. "Functional MRI allows us to measure permeability; understanding that characteristic alone can help clinicians better manage the patient's care," says Knopp.

Functional MRI can also reveal a tumor's interior landscape, or it's heterogeneity. Knopp says some tumors are extremely heterogeneous – meaning they are not biologically uniform. Instead, many may contain clusters of "hot spots," clumps of cells that are biologically different and often resistant to treatment. "Functional MRI can help us identify those areas, understand their particular features, and hopefully, design targeted therapies for those specific sites," says Knopp.

In functional MRI, images are made by measuring minute radio waves produced when hydrogen atoms in the body are trapped and vibrate within a magnetic field. The varying intensity of the signal reveals structural features and biological patterns illuminated by injected contrast agents.

"Analyzing data from those images can help us literally see where some chemotherapies are effective, and others are not. We know, for example, that in many cases, treatment with chemotherapy may kill 70 or 80 percent of a cancer, but the remaining tumor cells remain problematic. Now, we can find out exactly where those resistant areas are and we can be more selective and precise with additional treatment," says Knopp. (See http://www.jamesline.com/output/breastimages.htm for an illustration.)

While functional MRI offers new ways to visualize cancer at work, it presents several problems that need to be solved before it becomes routinely useful in clinical care. It is still so new that scientists have yet to agree on standard methodology they will use to visualize what they want to see. That makes comparing studies and findings across multiple centers difficult. In addition, one study alone can generate as many as 700-800 images that need to be synthesized and read collectively for a complete analysis – a process requiring substantial computational power and highly-trained specialists.

"It's an emerging field, and we think we are just beginning to see what it can do," says Knopp.

Knopp reviewed functional MRI in oncology in an article in the April issue of Molecular Cancer Therapeutics.


His research is supported by the National Cancer Institute,The Wright Center of Innovation and the Ohio Biomedical Research and Technology Transfer Fund.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map