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Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome.

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By Kavelaars A, Kuis W, Knook L, Sinnema G, Heijnen CJ. J Clin Endocrinol Metab 2000 Feb;85(2):692-6. Department of Pediatric Immunology, Wilhelmina Children's Hospital of the University Medical Center Utrecht, The Netherlands. • www.ProHealth.com • March 1, 2000


SUMMARY: Researchers in this study examined 15 adolescent girls with CFS and 14 healthy “control subject” girls who were of similar age. The results showed that those with CFS had immune systems that did not respond normally to the neuroendocrine system (hormones that influence the activity of nerves). Researchers concluded that CFS should be viewed as a disease of deficient neuroendocrine-immune communication.

STUDY: The present study was designed to investigate the interaction between neuroendocrine mediators and the immune system in chronic fatigue syndrome (CFS). We examined the sensitivity of the immune system to the glucocorticoid agonist dexamethasone and the beta2-adrenergic agonist terbutaline in 15 adolescent girls with CFS and 14 age- and sex-matched controls. Dexamethasone inhibits T-cell proliferation in healthy controls and in CFS patients. However, the maximal effect of dexamethasone on T-cell proliferation is significantly reduced in CFS patients as compared with controls. The beta2-adrenergic receptor agonist terbutaline inhibits tumor necrosis factor-alpha production and enhances interleukin-10 production by monocytes. Our data demonstrate that the capacity of a beta2-adrenergic agonist to regulate the production of these two cytokines is also reduced in CFS patients. We did not observe differences in baseline or CRH-induced cortisol and ACTH between CFS patients and controls. Baseline noradrenaline was similar in CFS and controls, whereas baseline adrenaline levels were significantly higher in CFS patients. We conclude that CFS is accompanied by a relative resistance of the immune system to regulation by the neuroendocrine system. Based on these data, we suggest CFS should be viewed as a disease of deficient neuroendocrine-immune communication.




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