ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Curcumin — A Novel Treatment Alternative for Depression

 
Print Page
Email Article

'Lost' Protein May Lead to New Prostate Cancer Treatment

  [ 21 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 10, 2003


Northwestern University researchers have found that a protein normally made in the body is critical for normal prostate growth regulation because mice that lack this protein develop an enlarged prostate. The excessive prostate growth in these animals resembles the human disease benign prostatic hyperplasia.

In an article published in the June issue of Nature Medicine, lead authors Jennifer Doll and Veronica Stellmach, with their colleagues at the Feinberg School of Medicine at Northwestern University in Chicago and Umea University in Sweden, presented their studies of a protein called pigment epithelium-derived factor (PEDF).

The observation of too many cells in the prostate of the PEDF-null mice led the researchers to examine PEDF in human prostates and prostate cancers, as well as in cells cultured from these tissues.

PEDF was easily detected in healthy prostate tissue and normal prostate cells, but little to no PEDF was detected in most of the prostate cancer tissue samples examined or in isolated prostate cancer cells grown in the lab.

Androgens, the male sex hormones that regulate prostate growth, were shown to inhibit the production of PEDF. Because androgen ablation (removal) therapy is an important part of prostate cancer treatment, the researchers measured PEDF production following androgen ablation in prostate cancer cells. They found that PEDF production appeared to be turned back on in the cells of these tumors.

One important role recently defined for PEDF was its potent activity as an inhibitor of angiogenesis, the growth of new blood vessels, which is required for tumor growth. To determine if PEDF may be affecting cells in a tumor in addition to the cells lining the blood vessels, the researchers examined the effects of purified PEDF on cultured prostate cancer cells. They found that PEDF triggered an increased rate of prostate cancer cell death, and that this effect was enhanced if the cells were oxygen deprived, which occurs in growing tumors.

The anti-tumor action of PEDF was confirmed when treatment of prostate tumors in mice with PEDF resulted in tumor cell death.

Doll is a research associate and Stellmach a research assistant professor of pathology at the Feinberg School. Their co-researchers at the Feinberg School were Noel P. Bouck, emeritus professor of microbiology-immunology and a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Chung Lee, John T. Grayhack Professor of Urology Research and Cancer Center researcher; Lisa P. Abramson; Mona L. Cornwell; Michael R. Pins, associate professor of pathology; Jayme Borensztan-Brentan, Floyd Elroy Patterson Research Professor of Pathology; and Susan E. Crawford, associate professor of pathology and Cancer Center researcher. Anders R.J. Bergh, Umea University, Umea, Sweden, also contributed to these studies.


This research was supported in part by grants from the National Institutes of Health and the Department of Defense.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map