ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

Probiotics improve cognition in Alzheimer's patients

The Onion: Cancer Fighter and Food Preserver

 
Print Page
Email Article

'Lost' Protein May Lead to New Prostate Cancer Treatment

  [ 21 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 10, 2003


Northwestern University researchers have found that a protein normally made in the body is critical for normal prostate growth regulation because mice that lack this protein develop an enlarged prostate. The excessive prostate growth in these animals resembles the human disease benign prostatic hyperplasia.

In an article published in the June issue of Nature Medicine, lead authors Jennifer Doll and Veronica Stellmach, with their colleagues at the Feinberg School of Medicine at Northwestern University in Chicago and Umea University in Sweden, presented their studies of a protein called pigment epithelium-derived factor (PEDF).

The observation of too many cells in the prostate of the PEDF-null mice led the researchers to examine PEDF in human prostates and prostate cancers, as well as in cells cultured from these tissues.

PEDF was easily detected in healthy prostate tissue and normal prostate cells, but little to no PEDF was detected in most of the prostate cancer tissue samples examined or in isolated prostate cancer cells grown in the lab.

Androgens, the male sex hormones that regulate prostate growth, were shown to inhibit the production of PEDF. Because androgen ablation (removal) therapy is an important part of prostate cancer treatment, the researchers measured PEDF production following androgen ablation in prostate cancer cells. They found that PEDF production appeared to be turned back on in the cells of these tumors.

One important role recently defined for PEDF was its potent activity as an inhibitor of angiogenesis, the growth of new blood vessels, which is required for tumor growth. To determine if PEDF may be affecting cells in a tumor in addition to the cells lining the blood vessels, the researchers examined the effects of purified PEDF on cultured prostate cancer cells. They found that PEDF triggered an increased rate of prostate cancer cell death, and that this effect was enhanced if the cells were oxygen deprived, which occurs in growing tumors.

The anti-tumor action of PEDF was confirmed when treatment of prostate tumors in mice with PEDF resulted in tumor cell death.

Doll is a research associate and Stellmach a research assistant professor of pathology at the Feinberg School. Their co-researchers at the Feinberg School were Noel P. Bouck, emeritus professor of microbiology-immunology and a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Chung Lee, John T. Grayhack Professor of Urology Research and Cancer Center researcher; Lisa P. Abramson; Mona L. Cornwell; Michael R. Pins, associate professor of pathology; Jayme Borensztan-Brentan, Floyd Elroy Patterson Research Professor of Pathology; and Susan E. Crawford, associate professor of pathology and Cancer Center researcher. Anders R.J. Bergh, Umea University, Umea, Sweden, also contributed to these studies.


This research was supported in part by grants from the National Institutes of Health and the Department of Defense.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map