ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Hormone Deficiency in Chronic Fatigue Syndrome (CFIDS) Patients?

  [ 47 votes ]   [ Discuss This Article ]
By Source: Health Watch • www.ProHealth.com • December 1, 1992


U.S. Department of Health and Human Services



New research has revealed hormonal deficiencies in the endocrine systems and brains of people with chronic fatigue syndrome (CFS). These findings may explain many of the symptoms of the disorder and could lead to new treatment strategies, according to scientists at the National Institute of Health and the Alcohol, Drug Abuse, and Mental Health Administration.



The study results were published this week by a collaborative team of researchers at the National Institute of Mental Health, the National Institute of Allergy and Infectious Diseases, and the National Institute of Child Health and Human Development.



All patients diagnosed with CFS have debilitating fatigue lasting at least six months that cannot be attributed to any other disease process. Other symptoms can also include feverishness, tender lymph glands, muscle and joint aches, sleep disturbances, depression and difficulty concentrating.



The prevalence of CFS has not yet been determined, although researchers at the Centers for Disease Control and NIAID-funded investigators are currently attempting to ascertain the number of CFS sufferers in the United States. Estimates range in the tens of thousands. Most people diagnosed with CFS are young adult women, but the condition occurs in people of all ages and races and of both sexes.



The research team found that on average, levels of cortisol, a hormone produced by the adrenal gland, were lower in the blood or urine of the 30 CFS patients studied than in the 72 normal volunteers tested. The body secretes cortisol in response to stress. Physicians have long known that even a subtle deficiency of cortisol can be associated with lethargy and fatigue.



Normally, when the body responds to a stressor-whether to an infectious viral or bacterial agent, an environmental toxin, or a psychological event—a complex series of events occurs in the endocrine (hormonal) system. The hypothalamus, a small area at the base of the brain, secretes a brain chemical called corticotropin releasing hormone (CRH), which activates the pituitary gland to secrete adrenocorticotropin hormone (ACTH). ACTH, in turn, stimulates the adrenal gland to produce cortisol.



The investigators concluded, based on a series of clinical tests involving the administration of small doses of CRH or ACTH, that the cortisol deficiency seen in patients with CFS resulted from a CRH deficiency.



In addition to controlling ACTH and cortisol secretion, CRH also helps to increase energy levels though its direct effect on the brain. A CRH deficiency by itself could, then, contribute to the lack of energy seen in people with CFS.



"Two hormonal abnormalities—a CRH deficiency and the resultant cortisol deficiency would each contribute to the overall symptoms and course of CFS," said the paper's first author, Mark A. Demitrack, M.D., previously with NIMH and now assistant professor of psychiatry at the University of Michigan Medical School.



The endocrine deficiency found in the study patients also offers a possible explanation for the depressive symptoms that some people with CFS experience.



"Dr. Gold noted that...there appears to be a hormonal imbalance in CFS patients."



"Our research indicates that the lower CRH levels evident in people with CFS also occur in patients with depressive syndromes fundamentally caused by biochemical imbalances," said Philip W. Gold, M.D., chief of NIMH's Neuroendocrinology Branch and senior author on the paper.



These illnesses not only include those traditionally characterized as mental disorders, such as specific subtypes of major depression, but also other medical disorders. For example. Dr. Gold said, the depressive syndrome associated with Cushing's disease and hypothyroidism also seems to occur in the context of a CRH deficiency.



"Finding a common central nervous system defect in these illnesses underscores the fact that they are all fundamentally medical disorders," Dr. Gold said.



The investigators suggest that insufficient stimulation of certain parts of the brain by cortisol or CRH could account for the lethargy and increased need for sleep seen in people with depressive syndromes as well as in those with CFS.



Further studies are in progress to determine which contributes most significantly to the fatigue in patients with CFS—the CRH deficiency or the cortisol deficiency alone, or the CRH and cortisol deficiencies together.



Stephen E. Straus, M.D., chief of NIAID's Laboratory of Clinical Investigation, who collaborated with the NIMH researchers on the study, has investigated various aspects of CFS for the past 12 years. He was originally intrigued by the possibility that a chronic infection could cause the disorder and lead to the high levels of antibodies to viruses that are found in many people with CFS. Antibodies are molecules produced as part of the body's protective response to ward off infectious agents or other foreign substances.



"There continue to be hints of viruses being associated with CFS," Dr. Straus said, "but I am excited by the alternative, new hypotheses raised about the syndrome by the current findings."



"Because cortisol is a potent suppressor of immune responses, a mild reduction in cortisol levels could allow the immune system to remain overactive, leading to findings such as higher-than-normal antibody levels," Dr. Straus said. Dr. Gold noted that it is important to point out that "this study does not imply damage to the endocrine glands or the brain. Instead, there appears to be a hormonal imbalance in CFS patients," he said.



Although the research findings have not proved that low CRLH and cortisol levels cause CFS, the investigators said, their results suggest that hormonal balance might be restored by treating patients with small amounts of cortisol.



"Cortisol treatment, however, is not without hazards," Dr. Gold said. "It would be simplistic and perhaps dangerous to treat patients with additional cortisol. If cortisol were given, it could signal to the hypothalamus that secretion of CRH is unnecessary because cortisol is in adequate supply. Thus, the CRH deficiency could be exacerbated," he added.



Despite these concerns, Dr. Straus said, "careful study could reveal a means to use the present findings to help alleviate the associated fatigue, lethargy, muscular aches and feverishness of CFS."



The study results were published in the December 1991 issue of the Journal of Clinical Endocrinology and Metabolism. In addition to Drs. Gold, Straus, and Demitrack, the authors include Markus J.P. Kruesi, M.D., and Sam J. Listwak, NIMH; Janet K. Dale, R.N., NIAID; and Louise Lave, M.D., and George P. Chrousos, M.D., NICHD.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map