ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Study on Nerve Cell Development May Hold Clues to Alzheimer’s Treatments

  [ 7 votes ]   [ Discuss This Article ]
By News Release • www.ProHealth.com • May 22, 2000


St. Louis, May 17, 2000 - Ann Marie Craig, Ph.D., an associate professor of anatomy and neurobiology at Washington University School of Medicine in St. Louis and a Pew Scholar in the Biomedical Sciences, has received a five-year $1.5 million grant from the National Institute of Neurological Disorders and Stroke. Craig is determining how proteins reach their correct sites in nerve cells.

Understanding protein trafficking in nerve cells could advance treatments for injury and Alzheimer's disease, where this process is disturbed. Identifying molecules that target proteins to axons or dendrites also may be useful for gene therapy and other applications that need to direct proteins to particular cellular locations.

To investigate protein targeting, Craig is studying a family of membrane proteins called metabotropic glutamate receptors. These receptors bind the neurotransmitter glutamate, resulting in signaling between pairs of cells. Different family members have related structures but activate different signaling pathways. Whereas some members function in dendrites, others function in axons.

Nerve cells have branches called dendrites that receive information and branches called axons that pass information to other cells. Different complements of proteins and other cellular constituents account for this polarity.

Craig and former graduate student Julia Stowell discovered that a receptor's tail serves as its admission ticket to the correct part of the cell, just as a ticket to New York gets a passenger on the right plane. Craig and postdoctoral associate Hélène Boudin, Ph.D., now will determine which part of a receptor makes it cluster within axons or dendrites at contact sites.

A second project will focus on the membranous sacs that transport proteins to dendrites or axons. The researchers will determine how many types of vesicles there are, look for associated components that direct them, and find out whether vesicles deliver their cargo into the cell's outer membrane only at certain sites.

A third project will identify proteins that interact with traffic signals and might help package, transport and anchor the receptors. The role of specific molecular



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Ultra EPA  - Fish Oil FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map