ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Natural Remedies for the Prevention of Dry Eyes

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

8 Chia Seed Recipes

Cinnamon Health Benefits Proven

 
Print Page
Email Article

Researchers Examine Alzheimer’s Treatment

  [ 2 votes ]   [ Discuss This Article ]
By News release • www.ProHealth.com • May 31, 2000


A cell receptor called RAGE may be a new potential target for compounds to treat or prevent Alzheimer's Disease.

Researchers at the University of Kentucky College of Medicine and the Columbia University College of Physicians and Surgeons have determined that a receptor -- called the receptor for advanced glycation endproducts (or RAGE) -- interacts with amyloid fibrils (small fibers containing starch). RAGE is a multiligand receptor, meaning that it interacts with many molecules. When RAGE interacts with the amyloid fibrils, it accelerates fibril formation and induces cellular dysfunction.

UK researchers disrupted the interaction of RAGE with amyloid fibrils two ways. They added additional amounts of soluble RAGE to neurons with amyloid fibrils. Because the RAGE molecules were not linked to cells, they could interact with the fibrils but not cause cellular dysfunction. They also added an antibody to RAGE that would bind to the receptor and prevent any interaction with amyloid fibrils.

Both methods suppressed amyloid formation in a systemic model of amyloid diseases, including Alzheimer's disease. By blocking RAGE with an antibody, the researchers found that the process of amyloid fibril deposition was reversed.

"The exciting thing about this research is that it suggests that RAGE may be a potential target for inhibiting amyloid fibril deposition, which would likely inhibit the progression of Alzheimer's disease," said one of the study’s authors, Mark Kindy.

About 4 million people nationwide have Alzheimer’s. A protein called amyloid-beta is thought to be critical in the disease’s development, although the exact role of amyloid-beta is unknown. Collections of amyloid-beta proteins, also called amyloid fibrils, are found in the brains of Alzheimer's patients and cause tissue damage and eventually death.

The study leaders were Shi Du Yan, M.D., assistant professor of pathology, and David Stern, M.D., professor of physiology and cellular biophysics and of surgery, both at the Columbia University College of Physicians and Surgeons, and Mark Kindy, Ph.D., associate professor of biochemistry at the UK College of Medicine, UK Sanders-Brown Center on Aging, Stroke Program at the UK Chandler Medical Center, and Veterans Affairs Medical Center in Lexington. The results of the research are published in the June issue of Nature Medicine.



Source: Eurekalert



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map