ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Trial Finds Reduction in Depressive Symptoms Following Magnesium Supplementation

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

 
Print Page
Email Article

Researchers Examine Alzheimer’s Treatment

  [ 2 votes ]   [ Discuss This Article ]
By News release • www.ProHealth.com • May 31, 2000


A cell receptor called RAGE may be a new potential target for compounds to treat or prevent Alzheimer's Disease.

Researchers at the University of Kentucky College of Medicine and the Columbia University College of Physicians and Surgeons have determined that a receptor -- called the receptor for advanced glycation endproducts (or RAGE) -- interacts with amyloid fibrils (small fibers containing starch). RAGE is a multiligand receptor, meaning that it interacts with many molecules. When RAGE interacts with the amyloid fibrils, it accelerates fibril formation and induces cellular dysfunction.

UK researchers disrupted the interaction of RAGE with amyloid fibrils two ways. They added additional amounts of soluble RAGE to neurons with amyloid fibrils. Because the RAGE molecules were not linked to cells, they could interact with the fibrils but not cause cellular dysfunction. They also added an antibody to RAGE that would bind to the receptor and prevent any interaction with amyloid fibrils.

Both methods suppressed amyloid formation in a systemic model of amyloid diseases, including Alzheimer's disease. By blocking RAGE with an antibody, the researchers found that the process of amyloid fibril deposition was reversed.

"The exciting thing about this research is that it suggests that RAGE may be a potential target for inhibiting amyloid fibril deposition, which would likely inhibit the progression of Alzheimer's disease," said one of the study’s authors, Mark Kindy.

About 4 million people nationwide have Alzheimer’s. A protein called amyloid-beta is thought to be critical in the disease’s development, although the exact role of amyloid-beta is unknown. Collections of amyloid-beta proteins, also called amyloid fibrils, are found in the brains of Alzheimer's patients and cause tissue damage and eventually death.

The study leaders were Shi Du Yan, M.D., assistant professor of pathology, and David Stern, M.D., professor of physiology and cellular biophysics and of surgery, both at the Columbia University College of Physicians and Surgeons, and Mark Kindy, Ph.D., associate professor of biochemistry at the UK College of Medicine, UK Sanders-Brown Center on Aging, Stroke Program at the UK Chandler Medical Center, and Veterans Affairs Medical Center in Lexington. The results of the research are published in the June issue of Nature Medicine.



Source: Eurekalert



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map