ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

On-and-off fasting helps fight obesity, study finds

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Low vitamin D levels predict ED in diabetics

What Benefits Can You Get From High-Quality Whey Protein?

 
Print Page
Email Article

Beneficial Effects of Insulin Versus Sulphonylurea on Insulin Secretion and Metabolic Control in Recently Diagnosed Type 2 Diabetic Patients

  [ 54 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 22, 2003


Clinical Care/Education/Nutrition

Michael Alvarsson, MD, PHD1, Göran Sundkvist, MD, PHD2, Ibe Lager, MD, PHD3, Marianne Henricsson, MD, PHD4, Kerstin Berntorp, MD, PHD2, Eva Fernqvist-Forbes, MD, PHD5, Lars Steen, MD6, Gunilla Westermark, MD, PHD7, Per Westermark, MD, PHD7, Thomas Örn, MD8 and Valdemar Grill, MD, PHD1

1 Department of Endocrinology and Diabetology, Karolinska Hospital, Stockholm, Sweden; 2 Department of Endocrinology, Malmö University Hospital, Malmö, Sweden; 3 Department of Medicine, Kristianstad Hospital, Kristianstad, Sweden; 4 Department of Ophthalmology, Helsingborg Hospital, Helsingborg, Sweden; 5 Department of Medicine, Visby Hospital, Visby, Sweden; 5 Department of Medicine, Mälarsjukhuset, Eskilstuna, Sweden; 6 Division of Cell Biology, Faculty of Health Sciences, Linköping, Sweden; 7 Department of Medicine, Blekingesjukhuset, Karlskrona, Sweden

Address correspondence and reprint requests to Michael Alvarsson, Department of Endocrinology and Diabetology, Karolinska Hospital, SE-171 76 Stockholm, Sweden. E-mail: michael.alvarsson@ks.se


OBJECTIVE—To evaluate whether treatment with insulin in recently diagnosed type 2 diabetes is advantageous compared with glibenclamide treatment.

RESEARCH DESIGN AND METHODS—ß-Cell function, glycemic control, and quality of life were monitored over 2 years in 39 patients with islet cell antibody-negative type 2 diabetes diagnosed 0–2 years before inclusion in a Swedish multicenter randomized clinical trial.

Patients were randomized to either two daily injections of premixed 30% soluble and 70% NPH insulin or glibenclamide (3.5–10.5 mg daily). C-peptide-glucagon tests were performed yearly in duplicate after 2–3 days of temporary withdrawal of treatment.

RESULTS—After 1 year the glucagon-stimulated C-peptide response was increased in the insulin-treated group by 0.14 ± 0.08 nmol/l, whereas it was decreased by 0.12 ± 0.08 nmol/l in the glibenclamide group, P < 0.02 for difference between groups.

After 2 years, fasting insulin levels were higher after treatment withdrawal in the insulin-treated versus the glibenclamide-treated group (P = 0.02). HbA1c levels decreased significantly during the first year in both groups; however, at the end of the second year, HbA1c had deteriorated in the glibenclamide group (P < 0.01), but not in the insulin-treated group. The difference in evolution of HbA1c during the second year was significant between groups, P < 0.02. A questionnaire indicated no difference in well-being related to treatment.

CONCLUSIONS—Early insulin versus glibenclamide treatment in type 2 diabetes temporarily prolongs endogenous insulin secretion and promotes better metabolic control.


Abbreviations: GADA, GAD antibody • IA2, insulinoma-associated protein 2 • IA-2A, IA2 antigen • ICA, islet cell anitbody • IAPP, islet amyloid polypeptide • LADA, latent autoimmune diabetes in adults • RIA, radioimmunoassay • UKPDS, U.K. Prospective Diabetes Study



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
"It's Not Easy Being Green" - But It Is Healthy
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Live Without Anxiety or Stress Live Without Anxiety or Stress

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map