ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Bladder Cancer Survival Rate Jumps

  [ 81 votes ]   [ Discuss This Article ] • August 27, 2003

HOUSTON –– Treating locally advanced bladder cancer with neoadjuvant chemotherapy –– chemotherapy before surgery –– can offer longer life to patients compared to the standard treatment of surgery alone, according to a study published in the August 28 issue of the New England Journal of Medicine.

In the 11-year study of 307 patients, conducted by the Southwest Oncology Group (SWOG) and led by an investigator at The University of Texas M. D. Anderson Cancer Center, researchers found that patients who received neoadjuvant chemotherapy lived an average of 31 months longer, and that those treated with surgery alone had a 66 percent greater chance of dying from bladder cancer than patients who had the combination therapy.

"This is an important advance, because the study shows a significant and clinically meaningful improvement in survival among patients who received chemotherapy before surgery," says the study's principal investigator, H. Barton Grossman, M.D., professor of urology at M. D. Anderson.

"Treatment of this disease varies across the country, but we believe neoadjuvant chemotherapy should be used more frequently to treat patients with locally advanced bladder cancer," he says.

Bladder cancer, considered a worldwide problem, is a leading tobacco-related cancer. In the United States, it is the fourth most common cancer in men and the eighth in women. According to the American Cancer Society, approximately 57,000 people are expected to be diagnosed with bladder cancer in this country in 2003 and an estimated 12,500 people will die of the disease.

Because of its tendency to spread, researchers have investigated a number of therapies to treat transitional cell bladder cancer (the most common form of the disease) which has invaded the bladder muscle and, therefore, is considered locally advanced. Studies to date have found that radiation therapy before surgery did not improve outcome.

With chemotherapy proving beneficial in patients with bladder cancer that had spread to other organs, SWOG began a randomized study in 1987 testing survival in patients who received surgery alone, versus patients treated with a three cycles of a chemotherapy combination known as M-VAC (methotrexate, vinblastine, doxorubicin, and cisplatin) before surgery. The study included 126 institutions around the country.

In all, 154 patients were assigned to receive surgery as primary treatment, and 153 patients received combination therapy. At the end of the study, researchers found that median survival between the two groups was significantly different. Patients treated with surgery lived a median of 41 months, compared to 77 months in patients treated with chemotherapy followed by surgery.

When the investigators looked at death rates from bladder cancer, they concluded that more patients treated with surgery alone died of the disease, and they died at a faster rate –– 77 patients died of bladder cancer in the surgery arm, compared to 54 in the combination treatment group. Patients treated with surgery alone had a 66 percent greater risk of dying from bladder cancer than patients who received neoadjuvant chemotherapy, according to the research team.

When overall death rates were considered –– death from any cause, not just bladder cancer –– the results were not as significant, Grossman says. After follow-up of more than eight years in each group, 90 deaths occurred in the combination therapy compared with 100 deaths in the group treated with surgery, meaning that patients who received surgery had a 33 percent greater chance of dying than patients treated with combination therapy, says Grossman. "These patients are generally older and may die of other causes, but the chance of surviving was higher in the neoadjuvant group," he says.

Patients who did best of all were those who had no cancer left in the bladder at the time of surgery, the researchers concluded. At the time of surgery, significantly more patients (38 percent) had no evidence of cancer remaining in bladder tissue, compared to 15 percent of patients who did not have prior chemotherapy.

"There were significantly more patients in the neoadjuvant group who had no residual disease compared to the surgery group and those are the patients that have much better survival. The chemotherapy effectively down-staged their cancer," says Grossman. "Ten years after treatment, some of those patients are still alive, so neoadjuvant chemotherapy before surgery provided a cure for them."

The study was supported by grants from the National Cancer Institute.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map