ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Natural Remedies for the Prevention of Dry Eyes

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

8 Chia Seed Recipes

Testosterone replacement therapy associated with improved urinary, sexual function

 
Print Page
Email Article

Study of Cellular Defect May Lead to New AD Drugs

  [ 6 votes ]   [ Discuss This Article ]
By xx • www.ProHealth.com • October 10, 2000


The discovery of two cellular mutations associated with early-onset Alzheimer’s could lead to the development of new drugs for the disease. A research team based at Massachusetts General Hospital (MGH) has discovered a key link between two cellular abnormalities – mutations in genes that produce proteins called presenilins and an altered handling of calcium inside cells.

The researchers have tied a specific calcium pathway to the production of amyloid-beta42, the sticky protein fragments that make up the plaques found in the brains of people with Alzheimer’s disease.

In the September issue of Neuron, scientists from the MGH Genetics and Aging Unit report that the presenilins appear to control a process that regulates the level of calcium in a cellular compartment called the endoplasmic reticulum. Researchers found that presenilin mutations usually associated with inherited Alzheimer’s disease slow down this regulatory process. They also show that inhibiting this particular calcium pathway increases production of amyloid-beta42 (A-beta42).

Rudolph Tanzi, PhD, director of the MGH Genetics and Aging Unit and a co-author of the ,i>Neuron paper, adds, "Our work predicts that, if you could develop a drug that stimulates this specific calcium pathway, you could lower levels of A-beta42, which is the name of the game in Alzheimer’s disease drug therapy development."

Mutations in two presenilin proteins – dubbed PS1 and PS2 – have been identified as causing most cases of inherited, early-onset Alzheimer’s disease, also called familial Alzheimer’s disease (FAD). The function of the presenilins is as yet unknown.

Some researchers have found evidence that one or both of them may be a sought-after enzyme called gamma-secretase that clips the large amyloid precursor protein (APP) to form A-beta fragments. Other recent Alzheimer’s research has shown that brain cells from people with FAD, or cells into which mutated presenilin genes have been inserted, show alterations in their handling of calcium, a process that is key to normal cellular metabolism.

Researchers have only recently discovered the pathway where calcium moves from outside the cell to storage inside the cell. By focusing on what is known as CCE, capacitated calcium entry, the research team hopes to figure out how to increase CCE and lower A-beta42, associated with early onset AD.

"If we can find compounds that increase CCE just enough to lower A-beta42, we may be able to offer a way to prevent or slow down the progression of Alzheimer’s to members of families affected by these mutations, some of whom begin to show symptoms at a very young age," Tanzi said. "While we currently don’t know whether this information also might be applied to the late-onset, non-inherited type of Alzheimer’s, we would assume that the pathways that go wrong in early-onset illness also are involved in late-onset disease."

Tanzi and Kim are currently working with Neurogenetics Inc., of San Diego to identify compounds that may lower A-beta42 by stimulating CCE. Both researchers are scientific founders and have equity interests in the company, which has licensed from the MGH the concept of treating Alzheimer’s through increasing CCE.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Optimized Curcumin Longvida® FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map