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www.ProHealth.com • September 26, 2003


Researchers testing almost all of the commonly prescribed drugs in the category of non-steroidal anti-inflammatories (NSAIDs) have found that flurbiprofen is especially effective in lowering levels of beta-amyloid 42, the protein fragment that is the prime suspect in Alzheimer’s disease. In another hopeful sign, R-flurbiprofen, the specific chemical variation with one of the greatest impacts on beta-amyloid 42, also fails to block the enzyme COX. Blocking of COX is an undesirable property of many NSAIDs that can lead to irritation and bleeding in the stomach and intestines as well as kidney damage.

These results are reported in the August 5, 2003 Journal of Clinical Investigation by Todd E. Golde, MD, PhD, Edward H. Koo, MD, and colleagues.

(Source: The Alzheimer's Association, online at www.alz.org.)



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