ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Ginkgo Give Your Brain a Boost?

Can Valerian Root Help You Sleep Better?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Curcumin — A Novel Treatment Alternative for Depression

How Glycation Accelerates Aging

 
Print Page
Email Article

Reminyl, New Treatment for Alzheimer's Disease, Receives FDA Approval

  [ 42 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 1, 2001


Reminyl® (galantamine hydrobromide) - a new treatment for mild to moderate Alzheimer's disease derived from the bulbs of daffodils - was approved today by the U.S. Food and Drug Administration (FDA).

Data from four placebo-controlled, double-blind clinical trials involving more than 2,650 patients show that Reminyl can have a beneficial effect on patients' daily function and ability to think. To be available by prescription in May, Reminyl was developed by the Janssen Research Foundation under a co-development and licensing agreement with the UK-based Shire Pharmaceuticals Group plc.

An estimated 4 million Americans have Alzheimer's disease, a progressive loss of cognitive function (thinking, remembering and reasoning) so severe that it interferes with an individual's ability to function. That number is expected to grow to 14 million by the middle of the next century. The disorder is the third-most-expensive illness in the United States, behind only heart disease and cancer.

"Alzheimer's disease patients progressively deteriorate," says Gary Small, MD, director of the Center on Aging and professor of psychiatry and biobehavioral sciences at the University of California in Los Angeles. "But the studies show that Reminyl can benefit many individuals with the disease. In studies lasting up to six months, many patients' symptoms initially improved or stabilized, and even when they begin to decline, they remained better than those who were treated with placebo [inactive medication]."

In studies ranging from 12 to 26 weeks, the effectiveness of Reminyl was measured using two primary tools. Patients' abilities related to memory, orientation, reasoning and language were assessed using the cognitive portion of the Alzheimer's Disease Assessment Scale (ADAS-cog). Across all studies, the results consistently demonstrated that more patients taking Reminyl showed significant improvement in their cognitive performance than those receiving placebo.

The second primary measure of effectiveness was the Clinician's Interview-Based Impression of Change plus Caregiver Information (CIBIC-plus), which provides an overall assessment of patient functioning - including behavior, organized thinking and activities of daily living (such as dressing, eating and managing family finances). The CIBIC-plus results from all studies also showed that the overall scores for patients taking Reminyl were statistically superior to placebo.

Reminyl will be available in 4 mg, 8 mg or 12 mg tablets. It should be taken by patients twice a day, preferably with meals. The approved product labeling recommends that physicians start by prescribing 8 mg of Reminyl per day (in two divided doses), then increase the dose to 16 mg after at least four weeks. Physicians have the flexibility to increase the daily dose to 24 mg after an additional four weeks.

With this recommended dosing regimen, the percentage of patients who dropped out of the clinical research due to side effects after taking Reminyl (7-10%) was comparable to the discontinuation rate for individuals receiving placebo (7%). Overall, the most common side effects experienced by patients who followed the recommended schedule for Reminyl were primarily gastrointestinal in nature. Side effects that occurred in 5% or greater of patients included nausea, vomiting, anorexia, diarrhea and weight loss.

"Reminyl is a major addition to Janssen's growing CNS [central nervous system] franchise. We are committed to improving the lives of both Alzheimer's disease patients and their caregivers," says Luc Truyen, MD, PhD, global medical leader for Reminyl with the Janssen Research Foundation. "In fact, support for family caregivers will be an important element of the educational programs we will initiate in conjunction with the introduction of Reminyl."

Reminyl also has been approved in 21 other countries to date, including most major European markets. Reminyl will be marketed by Janssen Pharmaceutica and Ortho-McNeil Pharmaceutical in the United States, Janssen-Ortho in Canada (approval pending) and Janssen-Cilag elsewhere - with the exception of the United Kingdom and Ireland, where it is registered and marketed by Shire under a co-promotion agreement with Janssen-Cilag.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map