ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Love Your Lungs With Tomatoes and Apples

How to Get Rid of Stretch Marks Naturally

Top Tips to Boost Your Immunity

Essential Oils Lower Blood Pressure

Vitamin D supplementation could ease IBS symptoms

11 Amazing Health Benefits of Using Baking Soda

 
Print Page
Email Article

Reminyl, New Treatment for Alzheimer's Disease, Receives FDA Approval

  [ 42 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 1, 2001


Reminyl® (galantamine hydrobromide) - a new treatment for mild to moderate Alzheimer's disease derived from the bulbs of daffodils - was approved today by the U.S. Food and Drug Administration (FDA).

Data from four placebo-controlled, double-blind clinical trials involving more than 2,650 patients show that Reminyl can have a beneficial effect on patients' daily function and ability to think. To be available by prescription in May, Reminyl was developed by the Janssen Research Foundation under a co-development and licensing agreement with the UK-based Shire Pharmaceuticals Group plc.

An estimated 4 million Americans have Alzheimer's disease, a progressive loss of cognitive function (thinking, remembering and reasoning) so severe that it interferes with an individual's ability to function. That number is expected to grow to 14 million by the middle of the next century. The disorder is the third-most-expensive illness in the United States, behind only heart disease and cancer.

"Alzheimer's disease patients progressively deteriorate," says Gary Small, MD, director of the Center on Aging and professor of psychiatry and biobehavioral sciences at the University of California in Los Angeles. "But the studies show that Reminyl can benefit many individuals with the disease. In studies lasting up to six months, many patients' symptoms initially improved or stabilized, and even when they begin to decline, they remained better than those who were treated with placebo [inactive medication]."

In studies ranging from 12 to 26 weeks, the effectiveness of Reminyl was measured using two primary tools. Patients' abilities related to memory, orientation, reasoning and language were assessed using the cognitive portion of the Alzheimer's Disease Assessment Scale (ADAS-cog). Across all studies, the results consistently demonstrated that more patients taking Reminyl showed significant improvement in their cognitive performance than those receiving placebo.

The second primary measure of effectiveness was the Clinician's Interview-Based Impression of Change plus Caregiver Information (CIBIC-plus), which provides an overall assessment of patient functioning - including behavior, organized thinking and activities of daily living (such as dressing, eating and managing family finances). The CIBIC-plus results from all studies also showed that the overall scores for patients taking Reminyl were statistically superior to placebo.

Reminyl will be available in 4 mg, 8 mg or 12 mg tablets. It should be taken by patients twice a day, preferably with meals. The approved product labeling recommends that physicians start by prescribing 8 mg of Reminyl per day (in two divided doses), then increase the dose to 16 mg after at least four weeks. Physicians have the flexibility to increase the daily dose to 24 mg after an additional four weeks.

With this recommended dosing regimen, the percentage of patients who dropped out of the clinical research due to side effects after taking Reminyl (7-10%) was comparable to the discontinuation rate for individuals receiving placebo (7%). Overall, the most common side effects experienced by patients who followed the recommended schedule for Reminyl were primarily gastrointestinal in nature. Side effects that occurred in 5% or greater of patients included nausea, vomiting, anorexia, diarrhea and weight loss.

"Reminyl is a major addition to Janssen's growing CNS [central nervous system] franchise. We are committed to improving the lives of both Alzheimer's disease patients and their caregivers," says Luc Truyen, MD, PhD, global medical leader for Reminyl with the Janssen Research Foundation. "In fact, support for family caregivers will be an important element of the educational programs we will initiate in conjunction with the introduction of Reminyl."

Reminyl also has been approved in 21 other countries to date, including most major European markets. Reminyl will be marketed by Janssen Pharmaceutica and Ortho-McNeil Pharmaceutical in the United States, Janssen-Ortho in Canada (approval pending) and Janssen-Cilag elsewhere - with the exception of the United Kingdom and Ireland, where it is registered and marketed by Shire under a co-promotion agreement with Janssen-Cilag.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map