ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplementation could ease IBS symptoms

Increase Your Magnesium Intake

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

Vitamin D deficiency during pregnancy can program obesity in children

 
Print Page
Email Article

Designer Estrogen may Help Prevent Cognitive Decline in Women over Seventy

  [ 42 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 8, 2001





The designer estrogen drug raloxifene has been prescribed to millions of postmenopausal women for osteoporosis, but its effects on the aging brain are unclear. A new study led by a University of California, San Francisco researcher shows that although raloxifene does not affect the cognitive performance of most women, it may help prevent decline among women older than 70 and women whose cognitive performance is declining regardless of age.

Raloxifene helped these groups of women to sustain better scores on tests of attention and verbal memory, according to Kristine Yaffe, MD, chief of geriatric psychiatry at San Francisco Veterans Affairs Medical Center, and UCSF assistant professor of psychiatry, neurology and epidemiology.

Over the last several years researchers had learned that raloxifene can work very much like estrogen on some systems in the body, but have opposite or anti-estrogen effects on others, Yaffe said. For example, raloxifene, like estrogen, can strengthen bones and reduce the risk of fractures in post-menopausal women. But while estrogen suppresses the hot flashes experienced by women at menopause, raloxifene does not decrease hot flashes and may occasionally induce them in some women.

While estrogen's effect on the brain still is unclear, some studies have suggested that it can help prevent the decline in cognitive function experienced by many older women. To assess whether raloxifene might have a similar effect, Yaffe and her colleagues analyzed the cognitive data gathered during the clinical trial called Multiple Outcomes of Raloxifene Evaluation (MORE), which showed the drug has beneficial effects on bone and can help reduce the risk of breast cancer.

"In general, raloxifene didn't help cognitive function, and it didn't hurt either. And that's reassuring for women given the previous concerns that is might be acting as an anti-estrogen, causing harm to the brain," Yaffe said.

In the trial, published in the April 19 issue of the New England Journal of Medicine, 7,705 post-menopausal women from hospitals and clinics in 25 countries were given daily doses of either raloxifene or a placebo for three years. All of the women were tested every year with six tests that measured various cognitive abilities, such as memory, attention, language, orientation, and visual-spatial skills.

Yaffe and her colleagues were interested in whether, for example, the scores of women taking placebo might decline more sharply than scores of women taking raloxifene.
For most women in the study, their scores declined little if at all, and raloxifene did not affect this decline significantly. "This indicates that raloxifene doesn't have much of an effect on healthy younger women after menopause," Yaffe said

However, she said, the study also suggested that raloxifene did make a difference for women older than 70, and the subgroup of women whose scores were declining substantially. Their scores declined less than the placebo group on two of the tests, which measured attention and verbal memory, suggesting that raloxifene might offer some protection against cognitive decline for these women.

Although these results aren't proof of a benefit, Yaffe said, they fit with some of the research on estrogen therapy for post-menopausal women, showing that it gives a small boost on tests of memory and attention. Also, she noted, "typically the first things affected in the early stages of Alzheimer's disease are verbal memory and attention."

The true test of whether raloxifene or estrogen protects against Alzheimer's disease or other types of dementia will be to track the women in the clinical trials for many more years to see whether one group is more likely to develop dementia. Yaffe and her colleagues are planning to do just that.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Safely Burn Away Body Fat Safely Burn Away Body Fat
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map