ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Designer Estrogen may Help Prevent Cognitive Decline in Women over Seventy

  [ 42 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 8, 2001





The designer estrogen drug raloxifene has been prescribed to millions of postmenopausal women for osteoporosis, but its effects on the aging brain are unclear. A new study led by a University of California, San Francisco researcher shows that although raloxifene does not affect the cognitive performance of most women, it may help prevent decline among women older than 70 and women whose cognitive performance is declining regardless of age.

Raloxifene helped these groups of women to sustain better scores on tests of attention and verbal memory, according to Kristine Yaffe, MD, chief of geriatric psychiatry at San Francisco Veterans Affairs Medical Center, and UCSF assistant professor of psychiatry, neurology and epidemiology.

Over the last several years researchers had learned that raloxifene can work very much like estrogen on some systems in the body, but have opposite or anti-estrogen effects on others, Yaffe said. For example, raloxifene, like estrogen, can strengthen bones and reduce the risk of fractures in post-menopausal women. But while estrogen suppresses the hot flashes experienced by women at menopause, raloxifene does not decrease hot flashes and may occasionally induce them in some women.

While estrogen's effect on the brain still is unclear, some studies have suggested that it can help prevent the decline in cognitive function experienced by many older women. To assess whether raloxifene might have a similar effect, Yaffe and her colleagues analyzed the cognitive data gathered during the clinical trial called Multiple Outcomes of Raloxifene Evaluation (MORE), which showed the drug has beneficial effects on bone and can help reduce the risk of breast cancer.

"In general, raloxifene didn't help cognitive function, and it didn't hurt either. And that's reassuring for women given the previous concerns that is might be acting as an anti-estrogen, causing harm to the brain," Yaffe said.

In the trial, published in the April 19 issue of the New England Journal of Medicine, 7,705 post-menopausal women from hospitals and clinics in 25 countries were given daily doses of either raloxifene or a placebo for three years. All of the women were tested every year with six tests that measured various cognitive abilities, such as memory, attention, language, orientation, and visual-spatial skills.

Yaffe and her colleagues were interested in whether, for example, the scores of women taking placebo might decline more sharply than scores of women taking raloxifene.
For most women in the study, their scores declined little if at all, and raloxifene did not affect this decline significantly. "This indicates that raloxifene doesn't have much of an effect on healthy younger women after menopause," Yaffe said

However, she said, the study also suggested that raloxifene did make a difference for women older than 70, and the subgroup of women whose scores were declining substantially. Their scores declined less than the placebo group on two of the tests, which measured attention and verbal memory, suggesting that raloxifene might offer some protection against cognitive decline for these women.

Although these results aren't proof of a benefit, Yaffe said, they fit with some of the research on estrogen therapy for post-menopausal women, showing that it gives a small boost on tests of memory and attention. Also, she noted, "typically the first things affected in the early stages of Alzheimer's disease are verbal memory and attention."

The true test of whether raloxifene or estrogen protects against Alzheimer's disease or other types of dementia will be to track the women in the clinical trials for many more years to see whether one group is more likely to develop dementia. Yaffe and her colleagues are planning to do just that.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Safely Burn Away Body Fat Safely Burn Away Body Fat
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map