ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

NYU Researchers Successfully Immunize Mice Against Alzheimer's

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 6, 2001




In a new study, researchers at the NYU School of Medicine have prevented the development of Alzheimer's disease in genetically engineered mice using a new vaccine that is safer than one currently used in early human clinical trials.

"Our study clearly shows that the vaccination approach is a powerful one that shows great promise for Alzheimer's disease," says Thomas Wisniewski, M.D., Associate Professor of Neurology, Pathology, and Psychiatry at NYU School of Medicine, "and significantly, our approach appears to be non-toxic," he said.

The researchers report that the new vaccine, modeled on a fragment of a protein called amyloid, which is most frequently implicated in causing Alzheimer's, reduced the amount of amyloid plaque in the brains of mice by 89 percent, and reduced the amount of soluble amyloid beta in the brain by 57 percent. The study is published in the August 2 issue of the American Journal of Pathology.

"We believe that our peptide vaccine isn't toxic to nerve cells because it doesn't aggregate into clumps; it remains in solution," says Blas Frangione, M.D., Ph.D., Professor of Pathology at NYU School of Medicine.

The first report of a vaccine against Alzheimer's in genetically engineered mice emerged less than two years ago using a vaccine made of a fragment of amyloid- precursor protein. This vaccine is now being tested in early clinical trials. But the NYU researchers are concerned that a vaccine based on this fragment could be toxic to nerve cells in the brain and may by itself trigger the formation of fibrils of plaque-forming amyloid. The NYU group set out to design a safer vaccine.

In previous studies, Dr. Frangione's group was able to block the formation of amyloid plaque in the brains of rats by creating a short peptide (a fragment of a protein) called a beta-sheet breaker. This peptide prevented the formation of a toxic, insoluble, helical form of amyloid that aggregates into so-called beta sheets and is deposited in plaques in the brain.

In the new study, Einar Sigurdsson, Ph.D., Research Assistant Professor at NYU School of Medicine, along with Drs. Wisniewski and Frangione, used the same principle to create a vaccine based on a modified, non-toxic peptide. They injected the new vaccine into 11-month-old mice genetically engineered with a human gene for Alzheimer's disease. At that age, the mice had already formed toxic amyloid plaques in the brain.

Seven months later, the researchers examined the brains of the mice. They found that the amount of the bad form of amyloid was reduced by 89 percent in the cortex, the seat of higher thought in the brain, and by 81 percent in the hippocampus, the brain's memory center, compared to the brains of a group of genetically engineered animals that didn't get the vaccine. Moreover, the vaccinated animals had 57 percent less soluble amyloid.

Alzheimer's is characterized by the destruction of nerve cells, especially in the areas of the brain vital to memory and learning. Round plaques composed of the amyloid protein are one of the hallmarks of the disease, and many researchers believe amyloid causes the death of nerve cells.

The NYU researchers believe that early clinical trials of the new vaccine could begin within one year.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map