ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplements, sleep could help manage pain

Bacopa: The Herb That May Increase Your Brain Power

Eat More Yogurt and Avoid Osteoporosis

Lilac Oil: More Than Just for Fragrance

What Is Bilberry Good For?

Coffee, herbal tea may help prevent liver fibrosis

Crafty Uses for Carrot Seed Oil

Higher omega 3 levels linked to improved brain blood flow

Curcumin, resveratrol, ursolic acid show promise against prostate cancer

Olive oil compound could help protect against brain cancer

 
Print Page
Email Article

Identifying cancer genes – Will it really lead to better treatment?

  [ 15 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 23, 2003


Copenhagen, Denmark: A systematic trawl through the human genome looking for the abnormalities that drive cancer is already producing promising results, a scientist told ECCO 12 – The European Cancer Conference in Copenhagen today (Tuesday 23 September).

Dr. Michael Stratton, Director of the Cancer Genome Project at the Wellcome Trust Sanger Institute, Cambridge, UK, described how his study of the BRAF mutation could provide new targets for drug development, which could lead to better targeted – or even individualised - treatment for cancer patients.

The decoding of the human genome has allowed scientists to compare the normal DNA sequence with that seen in cancers, and hence identify abnormalities. The BRAF mutation is implicated in a number of common cancers, according to Dr. Stratton. It appears to be involved in the switching mechanism of the gene, and is found in 70% of melanomas, in 30% of some types of thyroid and ovarian cancer, and in 10% of colorectal tumours.

Over 80% of the mutations bring about a single change in an amino acid, making it a relatively simple target for rectification. "Once we can identify this kind of abnormal biological process", said Dr. Stratton. "we can move on to the next stage – developing drugs to prevent or correct it."

The traditional approach to research in cancer has been the comparison of treatments through randomised clinical trials, with the extrapolation of an average benefit to the individual. This often means that many patients are inefficiently treated, while only a few benefit. Gene targets herald a different approach, and are becoming increasingly important in the search for effective cancer treatments.

Genes are implicated in cancer in a number of ways – as oncogenes, which drive cancer forward, as tumour suppressor genes that slow down cell division, and as DNA repair genes, which help to keep chromosomes intact when genetic mutation occurs.

A small number of drugs targeted at mutated cancer genes have already been shown to act effectively. "Undoubtedly, these advances have changed the way we think about cancer drug development. BRAF is a promising target and we have initiated a program of drug development targeted at this gene. Early lead molecules have already been found and are now being developed further," said Dr. Stratton.

"However, we must temper our general optimism with caution. We still have much to learn about this new strategy of targeting drugs at abnormal cancer genes. Moreover, drug development is a slow process that can take more than a decade before clinical trials are completed and the effectiveness of the drug is finally known," he said.



Abstract no: 355 (Tuesday 23 September, 14.15 hrs CET, Oncogenomics – biological insights and clinical applications session).



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Breaking Through the Mental Fog Breaking Through the Mental Fog
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map