ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Hormone replacement therapy associated with lower risk of dying over eight year follow-up period

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

 
Print Page
Email Article

NIH adds $1.1 million to USF Alzheimer's Vaccine Research

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 26, 2001




The University of South Florida's work to refine a promising vaccine for Alzheimer's disease was boosted by a new $1.1-million National Institutes of Health grant. The award will help researchers test cellular immune responses to the beta amyloid vaccine in a "humanized" mouse model, which shows brain pathology and memory losses similar to those in Alzheimer's disease.

This more advanced mouse model, to be jointly developed by USF and the University of Pennsylvania, may help explain the potential role that cellular immunity plays in fighting or promoting the devastating neurodegenerative disease.

"We want a more well-rounded, extensive understanding of the immunological responses to the Alzheimer's vaccine, particularly potential cellular immunity, to determine whether the responses are beneficial or not," Kenneth Ugen, PhD, associate professor of medical microbiology and immunology and principal investigator of the newly funded grant. "Furthermore, the research is important to the vaccine's future effectiveness and safety in humans."

The researchers will also work on developing a DNA vaccine against Alzheimer's disease, which may have technological or economical advantages over conventional vaccination methods.

This second National Institute on Aging grant is in addition to a $2.2-milliion NIA grant awarded last year to David Morgan, PhD, and professor of pharmacology. Dr. Morgan co-principal investigator, heads the USF Alzheimer's vaccine research program, which includes Dr. Ugen as one of its major investigators. Earlier work by the USF group showed that an experimental vaccine prevented memory loss in mice with mutated human genes (known as transgenic mice) that produce age-related brain degeneration much like Alzheimer's disease. The study, published in the journal Nature, attracted international attention.

The researchers plan to cross two lines of transgenic mice to produce a new mouse model for Alzheimer's disease. Mice carrying the human genes for MHC I and MHC II (major histocompatibility molecules I and II), provided by Dr. Weiner's lab, will be mated with the transgenic Alzheimer's mice developed at USF. MHCI and MHCII, present on the surface of cells, are important in helping the body to recognize certain foreign substances, or antigens, as harmful. "The resulting offspring will be mice expected to respond to the anti-Alzheimer's vaccine with more human-like immune reactions," Dr. Ugen said.

The researchers will inject the mice bred to develop age-related neurodegeneration with the anti-Alzheimer's vaccine, which contains as its antigen a synthetic version of beta amyloid, the protein that builds up in the brains of Alzheimer's patients. Then, they will analyze the responses of immune cells to the vaccine. They will look for harmful side effects and, in particular, study the role of cellular immunity in any beneficial effects from the vaccine.

Vaccines traditionally protect against viruses or bacteria that invade the body from outside sources. The anti-Alzheimer's vaccine works by triggering the immune system to recognize beta amyloid -- a protein made by the body -- as a foreign invader and attack it. "We're dealing here with the new use of a vaccine to fight a chronic neurodegenerative disease," said Dr. Morgan, a co-investigator for the study.

"It is still unclear whether the cellular immune response to the vaccine is good or bad. In trying to provoke an immune response that prevents or removes the buildup of beta amyloid deposits in the brain, it may inadvertantly be creating other autoimmune reactions against nerve or muscle fibers that could be damaging."

Learning more about vaccine-induced immunity is expected to help researchers formulate a reliable vaccine that will work most safely and effectively for the large population of people at potential risk for Alzheimer's disease.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Break Free From Fibromyalgia Break Free From Fibromyalgia
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map