ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

Probiotics improve cognition in Alzheimer's patients

The Onion: Cancer Fighter and Food Preserver

 
Print Page
Email Article

NIH adds $1.1 million to USF Alzheimer's Vaccine Research

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 26, 2001




The University of South Florida's work to refine a promising vaccine for Alzheimer's disease was boosted by a new $1.1-million National Institutes of Health grant. The award will help researchers test cellular immune responses to the beta amyloid vaccine in a "humanized" mouse model, which shows brain pathology and memory losses similar to those in Alzheimer's disease.

This more advanced mouse model, to be jointly developed by USF and the University of Pennsylvania, may help explain the potential role that cellular immunity plays in fighting or promoting the devastating neurodegenerative disease.

"We want a more well-rounded, extensive understanding of the immunological responses to the Alzheimer's vaccine, particularly potential cellular immunity, to determine whether the responses are beneficial or not," Kenneth Ugen, PhD, associate professor of medical microbiology and immunology and principal investigator of the newly funded grant. "Furthermore, the research is important to the vaccine's future effectiveness and safety in humans."

The researchers will also work on developing a DNA vaccine against Alzheimer's disease, which may have technological or economical advantages over conventional vaccination methods.

This second National Institute on Aging grant is in addition to a $2.2-milliion NIA grant awarded last year to David Morgan, PhD, and professor of pharmacology. Dr. Morgan co-principal investigator, heads the USF Alzheimer's vaccine research program, which includes Dr. Ugen as one of its major investigators. Earlier work by the USF group showed that an experimental vaccine prevented memory loss in mice with mutated human genes (known as transgenic mice) that produce age-related brain degeneration much like Alzheimer's disease. The study, published in the journal Nature, attracted international attention.

The researchers plan to cross two lines of transgenic mice to produce a new mouse model for Alzheimer's disease. Mice carrying the human genes for MHC I and MHC II (major histocompatibility molecules I and II), provided by Dr. Weiner's lab, will be mated with the transgenic Alzheimer's mice developed at USF. MHCI and MHCII, present on the surface of cells, are important in helping the body to recognize certain foreign substances, or antigens, as harmful. "The resulting offspring will be mice expected to respond to the anti-Alzheimer's vaccine with more human-like immune reactions," Dr. Ugen said.

The researchers will inject the mice bred to develop age-related neurodegeneration with the anti-Alzheimer's vaccine, which contains as its antigen a synthetic version of beta amyloid, the protein that builds up in the brains of Alzheimer's patients. Then, they will analyze the responses of immune cells to the vaccine. They will look for harmful side effects and, in particular, study the role of cellular immunity in any beneficial effects from the vaccine.

Vaccines traditionally protect against viruses or bacteria that invade the body from outside sources. The anti-Alzheimer's vaccine works by triggering the immune system to recognize beta amyloid -- a protein made by the body -- as a foreign invader and attack it. "We're dealing here with the new use of a vaccine to fight a chronic neurodegenerative disease," said Dr. Morgan, a co-investigator for the study.

"It is still unclear whether the cellular immune response to the vaccine is good or bad. In trying to provoke an immune response that prevents or removes the buildup of beta amyloid deposits in the brain, it may inadvertantly be creating other autoimmune reactions against nerve or muscle fibers that could be damaging."

Learning more about vaccine-induced immunity is expected to help researchers formulate a reliable vaccine that will work most safely and effectively for the large population of people at potential risk for Alzheimer's disease.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map