ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

Probiotics improve cognition in Alzheimer's patients

The Onion: Cancer Fighter and Food Preserver

SURVEY RESULTS: Cognitive Impairment II

 
Print Page
Email Article

Research: Chromium Picolinate May Enhance Insulin Sensitivity

  [ 187 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 26, 2003


New clinical study uncovers mechanism by which chromium picolinate may enhance insulin sensitivity

Effective and safe complementary nutrition therapy

PARIS, France, August 28, 2003 – The results of a new double-blind randomized placebo controlled human trial of people with type 2 diabetes revealed a potential mechanism that may explain the ability of chromium picolinate to improve insulin resistance in human skeletal muscle – the primary site for glucose metabolism.

These data suggest that when chromium picolinate is added to the diet, insulin sensitivity improves for people with diabetes, a chronic disease that affects 194 million people worldwide. The findings were presented by Dr. William T. Cefalu from the University of Vermont College of Medicine at the 18th International Diabetes Federation Congress.

Research suggests that the potential in vivo mechanism of chromium picolinate on insulin action in human skeletal muscle may occur by increasing the activation of Akt phosphorylation -- an intracellular insulin dependent protein that facilitates the uptake of glucose into cells.

"This study demonstrates that those individuals with type 2 diabetes who supplemented their diet with chromium picolinate had an enhanced activity of the protein compared to those who were on placebo," stated Dr. Cefalu. "As this intracellular pathway is implicated in contributing to insulin resistance, this represents a possible mechanism to explain chromium picolinate's beneficial effect on insulin sensitivity as observed in several clinical studies."

The clinical trial

The double-blind, placebo controlled trial, included two cohorts of subjects with type 2 diabetes who were treated with either sulfonylureas (a class of diabetic drugs that increase insulin secretion), or a diet program. Both groups were randomized to receive either chromium picolinate (1000 mcg) daily or placebo.

The most accurate measure of insulin sensitivity, hyperinsulinemic, euglycemic clamp studies, were used to assess the efficacy of glucose uptake on all subjects prior to randomization and at the end of the study. Of the 16 subjects, those randomized to chromium picolinate had a mean increase in insulin sensitivity of 8.9%, while the placebo group had a mean decrease of 3.6%. In addition, insulin-stimulated Akt activation was significantly increased at the end of the study compared to those subjects on placebo. No adverse events were reported.

The World Health Organization (WHO) estimates that four to five percent of health budgets are spent on diabetes-related illnesses and that people with diabetes incur medical costs two to five times higher than people without diabetes.

Chromium is an essential mineral that is a co-factor of insulin. "By applying rigorous science, we hope to show it's potential to improve the quality of patient care for people with diabetes and reduce cost of therapy," said James Komorowski, MS, Vice President of Technical Services and Scientific Affairs, Nutrition 21, Inc., which supplied Chromax® chromium picolinate for the study.

Chromax® chromium picolinate is the most clinically tested brand of chromium with proven efficacy for support of glucose metabolism. "This new research further supports the large body of scientific evidence showing chromium picolinate is a safe and effective addition to the diet for people with type 2 diabetes seeking optimal control of their blood sugar levels."



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map