ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

Why the Mediterranean Diet Is so Successful

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Wearable biosensors can flag illness, Lyme disease, risk for diabetes; low airplane oxygen

VIDEO: The Best Brain Foods That Help Increase Your Memory!

More evidence for calorie restriction’s longevity effect

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

 
Print Page
Email Article

Melatonin levels in women with fibromyalgia (FM) & Chronic Fatigue Syndrome (CFS)

  [ 11 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 5, 1999


OBJECTIVE: Fibromyalgia (FM) and chronic fatigue syndrome
(CFS) are stress associated disorders mainly affecting women.
FM is characterized primarily by widespread musculoskeletal
pain, and CFS by profound debilitating fatigue, but there is
considerable overlap of clinical symptoms between these 2
syndromes. Neuroendocrine abnormalities have been noted in
both FM and CFS and desynchronization of circadian systems has
been postulated in their etiology. The pineal hormone
melatonin is involved in synchronizing circadian systems and
the use of exogenous melatonin has become widespread in
patients with FM and CFS.

METHODS: We examined the
characteristics and relationship of melatonin and cortisol
levels in premenopausal women with FM (n = 9) or CFS (n = 8),
compared to age and menstrual cycle phase matched controls.
Blood was collected from an indwelling intravenous catheter
every 10 min over 24 h, and plasma melatonin and cortisol were
determined by radioimmunoassay at 60 and 10 min intervals,
respectively.

RESULTS: Night time (23:00-06:50) plasma
melatonin levels were significantly higher in FM patients
compared to controls (p<0.05), but there was no significant
difference in melatonin levels between CFS patients and
controls. No differences in the timing of cortisol and
melatonin secretory patterns and no internal desynchronization
of the 2 rhythms were found in either patient group, compared
to controls.

CONCLUSION: Raised plasma melatonin
concentrations have been documented in several other
conditions that are associated with dysregulation of
neuroendocrine axes. Increased melatonin levels may represent
a marker of increased susceptibility to stress induced
hypothalamic disruptions. These data indicate that there is no
rationale for melatonin replacement therapy in patients with
FM and CFS.

Korszun A, Sackett-Lundeen L, Papadopoulos E, Brucksch C, Masterson
L, Engelberg NC, Haus E, Demitrack MA, Crofford L




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map