ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Melatonin levels in women with fibromyalgia (FM) & Chronic Fatigue Syndrome (CFS)

  [ 11 votes ]   [ Discuss This Article ] • December 5, 1999

OBJECTIVE: Fibromyalgia (FM) and chronic fatigue syndrome
(CFS) are stress associated disorders mainly affecting women.
FM is characterized primarily by widespread musculoskeletal
pain, and CFS by profound debilitating fatigue, but there is
considerable overlap of clinical symptoms between these 2
syndromes. Neuroendocrine abnormalities have been noted in
both FM and CFS and desynchronization of circadian systems has
been postulated in their etiology. The pineal hormone
melatonin is involved in synchronizing circadian systems and
the use of exogenous melatonin has become widespread in
patients with FM and CFS.

METHODS: We examined the
characteristics and relationship of melatonin and cortisol
levels in premenopausal women with FM (n = 9) or CFS (n = 8),
compared to age and menstrual cycle phase matched controls.
Blood was collected from an indwelling intravenous catheter
every 10 min over 24 h, and plasma melatonin and cortisol were
determined by radioimmunoassay at 60 and 10 min intervals,

RESULTS: Night time (23:00-06:50) plasma
melatonin levels were significantly higher in FM patients
compared to controls (p<0.05), but there was no significant
difference in melatonin levels between CFS patients and
controls. No differences in the timing of cortisol and
melatonin secretory patterns and no internal desynchronization
of the 2 rhythms were found in either patient group, compared
to controls.

CONCLUSION: Raised plasma melatonin
concentrations have been documented in several other
conditions that are associated with dysregulation of
neuroendocrine axes. Increased melatonin levels may represent
a marker of increased susceptibility to stress induced
hypothalamic disruptions. These data indicate that there is no
rationale for melatonin replacement therapy in patients with
FM and CFS.

Korszun A, Sackett-Lundeen L, Papadopoulos E, Brucksch C, Masterson
L, Engelberg NC, Haus E, Demitrack MA, Crofford L

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map