ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplementation could ease IBS symptoms

Increase Your Magnesium Intake

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

Vitamin D deficiency during pregnancy can program obesity in children

Print Page
Email Article

Mice with COX-2 Protein Exhibit Memory Loss Similar to Alzheimer's Disease

  [ 17 votes ]   [ Discuss This Article ] • December 3, 2001

A new study shows mice engineered to make the human COX-2 protein, develop memory problems and mimic symptoms found in Alzheimer's disease. This is according to a recent presentation by scientists from the Johns Hopkins School of Medicine, and the biomedical research company Pharmacia at the annual meeting of the Society for Neuroscience.

"The really exciting thing is that this protein is turning out to be involved in so many things, and we already have the means to target it, to block it," says Katrin Andreasson, M.D., assistant professor of neurology and neuroscience at Johns Hopkins. "It makes it very conceivable that in the years to come we could prevent these diseases."

Drugs that reduce swelling, like ibuprofen and newer anti-inflammatories like Celebrex and Vioxx, work by blocking COX-2. However, Andreasson cautions that a lot of work remains in order to learn whether these drugs might prevent neurological disease or damage in people.

The researchers measured the animals' abilities to learn and remember using a variety of tests, including mazes and swimming tests. The animals' behaviors in the test situations reflected how brain levels of the human COX-2 protein affected their learning and memory at different ages. The more COX-2 protein the mice make in their brains, the more pronounced the memory problems became, and the faster those problems developed.

"The effect of having lots of the human COX-2 protein is remarkable in these mice," says Andreasson. "At age seven months -- roughly similar to humans in their 20s and 30s -- they are fine, but as these mice get older they exhibit progressively greater memory deficits. These mice have real age-dependent memory loss, and higher age-dependent loss of brain cells that parallels the behavioral changes."

Because so much is already known about the human COX-2 protein, learning more about what it does in the brain, even the mouse brain, is a little easier, says Andreasson. "We already have tools to see where COX-2 is located in the brain and in individual nerve cells, and we can also test whether it's working by measuring levels of the molecules it makes."

COX-2 helps make a group of five molecules, called prostaglandins that send signals to the nerve cell. Andreasson says one of the prostaglandins may be the real culprit behind COX-2's effects on memory and it's role in disease.

"If it's a prostaglandin, we can find out which is good and which is bad, and potentially target the bad one specifically to prevent memory loss or damage from aging or stroke or disease," she says. "The possibility would exist to prevent neurological problems and to do so with fewer side effects than blocking COX-2 itself."

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® FibroSleep™ Mitochondria Ignite™ with NT Factor®

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
The Fibromyalgia and Glutathione Link The Fibromyalgia and Glutathione Link
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map