ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

Print Page
Email Article

Genetic Alteration Predisposes some Hispanics to Early-onset Alzheimer's Disease

  [ 82 votes ]   [ Discuss This Article ] • December 5, 2001

A unique genetic change associated with the development of early-onset Alzheimer's disease in Caribbean Hispanics has been identified by Columbia University College of Physicians & Surgeons researchers. This newly recognized variation in the presenilin 1 gene also seems to trace back to a common ancestor.

The findings, published in the Nov. 14 issue of the Journal of the American Medical Association should allow physicians to use mutation analysis to better diagnose the neurodegenerative disease in certain families of Caribbean Hispanic heritage, and to genetically counsel family members with a familial risk for the disorder.

"This is the first genetic alteration characterized for early-onset Alzheimer's disease in the Caribbean Hispanic population," said Dr. Richard Mayeux, director of the Gertrude H. Sergievsky Center and co-director of the Taub Institute on Alzheimer's Disease. "The mutation should help us diagnose early-onset Alzheimer's disease in this population group. And Caribbean Hispanics under age 60 who have a history of Alzheimer's disease may consider getting screened for this mutation."

Clinicians recognize two types of Alzheimer's disease: familial, in which multiple family members are affected, and sporadic, when only one member in a family has the disease. They further distinguish early-onset Alzheimer's, which affects people between the ages of 30 and 60, and late-onset disease, which is usually diagnosed in people who are at least 65.

Early-onset disease, which accounts for only 10 percent to 15 percent of the cases, is strongly hereditary. Late-onset is the more common form of the disease, which can be both genetic and sporadic.

In the study, the researchers analyzed the DNA of 44 individuals in 19 families of Caribbean Hispanic descent who had been diagnosed with early-onset Alzheimer's disease. They looked for the presence of genetic changes or mutations in two genes, presenilin 1 and amyloid precursor protein.

Scientists already had found an association between early-onset Alzheimer's disease and these two genes in other populations. The investigators focused on Caribbean Hispanics because the frequency of Alzheimer's disease is higher among Hispanics in general and in this population in particular, compared with non-Hispanic whites. Columbia researchers reported the increased risk of Alzheimer's disease among Caribbean Hispanics earlier this year in Neurology.

"But Caribbean Hispanic families have not typically been included in comprehensive studies of the genetic determinants of early-onset Alzheimer's disease," Dr. Mayeux says.
The investigators performed the genetic analysis on families living in Northern Manhattan, many of whom emigrated from the Dominican Republic to the United States, and on families currently living in the Dominican Republic.

They found 18 unrelated families had the exact same genetic mutation at a specific location in the presenilin 1 gene. The mutation results in the amino acid alanine to be put into the presenilin protein instead of glycine.

Experiments with cultured cells containing the mutated gene revealed the alteration causes an increase in the expression of the toxic form of beta amyloid, a substance usually found in the brains of Alzheimer's patients. The researchers also found that all the families shared certain unique genetic similarities in a region of DNA that flanked the gene, indicating that these families had all shared a common ancestor at some point in history.

Not every Caribbean Hispanic family with early-onset Alzheimer's disease in the study had the mutation, however. The Columbia researchers currently are screening more than 200 Caribbean Hispanic families that have at least two individuals affected by all types of Alzheimer's disease for a wide range of genetic markers. One or several of these may someday be shown to be associated with the devastating disease in this population and in others.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map