ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Can You Benefit From Vitamin B12?

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

A Breathalyzer for Disease?

Why You Should Be Eating More Porcini Mushrooms

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

 
Print Page
Email Article

The growth hormone (GH)-releasing hormone-GH-insulin-like growth

  [ 370 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 4, 1999


Fibromyalgia (FM) is a painful syndrome of nonarticular
origin, characterized by fatigue and widespread
musculoskeletal pain, tiredness, and sleep disturbances,
without any other objective findings on examination.
Interestingly, some of the clinical features of FM resemble
the ones described in the adult GH-deficiency syndrome.
Furthermore, insulin-like growth factor (IGF)-1 levels are
frequently reduced in patients with FM. To gain further
insight into the mechanisms leading to dysregulation of the
GH-IGF-1 axis in these patients, we assessed 24-h spontaneous
GH secretion, GH responses to GHRH, and IGF-1 and IGF binding
protein (BP)-3 levels before and after 4 days treatment with
human (h)GH. We found that, in comparison with controls,
patients with FM exhibited a marked decrease in spontaneous GH
secretion as assessed by mean GH secretion (2.5 +/- 0.4
microg/L in controls vs. 1.2 +/- 0.1 microg/L in FM, P <
0.05), pulse height (4.7 +/- 0.8 microg/L in controls vs. 2.5
+/- 0.3 microg/L in FM, P < 0.05), and pulse area (4.7 +/- 1
min/mg x L in controls vs. 2.3 +/- 0.3 min/mg x L in FM, P <
0.05). In contrast, GH responses to GHRH (100 microg, i.v.)
were similar in controls (mean peak, 13.5 +/- 2.5 microg/L)
and in patients with FM (12.2 +/- 3 microg/L). Finally,
treatment with hGH (2 IU, s.c. daily), over 4 days, led to a
clear-cut increase in plasma IGF-1 and IGFBP-3 levels in
patients with FM. In conclusion, our data show that patients
with FM exhibited a marked decrease in spontaneous GH
secretion, but normal pituitary responsiveness to exogenously
administered GHRH, thus suggesting the existence of an
alteration at the hypothalamic level in the neuroendocrine
control of GH in these patients. Furthermore, our finding of
increased IGF-1 and IGFBP-3 levels after GH treatment, over 4
days, opens up the possibility of testing the therapeutic
potential of hGH in patients with FM.


Leal-Cerro A, Povedano J, Astorga R, Gonzalez M, Silva H,
Garcia-Pesquera F, Casanueva FF, Dieguez C




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra ATP+, Double Strength Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
"It's Not Easy Being Green" - But It Is Healthy
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map