ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Print Page
Email Article

The growth hormone (GH)-releasing hormone-GH-insulin-like growth

  [ 370 votes ]   [ Discuss This Article ] • September 4, 1999

Fibromyalgia (FM) is a painful syndrome of nonarticular
origin, characterized by fatigue and widespread
musculoskeletal pain, tiredness, and sleep disturbances,
without any other objective findings on examination.
Interestingly, some of the clinical features of FM resemble
the ones described in the adult GH-deficiency syndrome.
Furthermore, insulin-like growth factor (IGF)-1 levels are
frequently reduced in patients with FM. To gain further
insight into the mechanisms leading to dysregulation of the
GH-IGF-1 axis in these patients, we assessed 24-h spontaneous
GH secretion, GH responses to GHRH, and IGF-1 and IGF binding
protein (BP)-3 levels before and after 4 days treatment with
human (h)GH. We found that, in comparison with controls,
patients with FM exhibited a marked decrease in spontaneous GH
secretion as assessed by mean GH secretion (2.5 +/- 0.4
microg/L in controls vs. 1.2 +/- 0.1 microg/L in FM, P <
0.05), pulse height (4.7 +/- 0.8 microg/L in controls vs. 2.5
+/- 0.3 microg/L in FM, P < 0.05), and pulse area (4.7 +/- 1
min/mg x L in controls vs. 2.3 +/- 0.3 min/mg x L in FM, P <
0.05). In contrast, GH responses to GHRH (100 microg, i.v.)
were similar in controls (mean peak, 13.5 +/- 2.5 microg/L)
and in patients with FM (12.2 +/- 3 microg/L). Finally,
treatment with hGH (2 IU, s.c. daily), over 4 days, led to a
clear-cut increase in plasma IGF-1 and IGFBP-3 levels in
patients with FM. In conclusion, our data show that patients
with FM exhibited a marked decrease in spontaneous GH
secretion, but normal pituitary responsiveness to exogenously
administered GHRH, thus suggesting the existence of an
alteration at the hypothalamic level in the neuroendocrine
control of GH in these patients. Furthermore, our finding of
increased IGF-1 and IGFBP-3 levels after GH treatment, over 4
days, opens up the possibility of testing the therapeutic
potential of hGH in patients with FM.

Leal-Cerro A, Povedano J, Astorga R, Gonzalez M, Silva H,
Garcia-Pesquera F, Casanueva FF, Dieguez C

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Vitamin D3 Extreme™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Safely Burn Away Body Fat Safely Burn Away Body Fat
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map