ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

The growth hormone (GH)-releasing hormone-GH-insulin-like growth

  [ 370 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 4, 1999


Fibromyalgia (FM) is a painful syndrome of nonarticular
origin, characterized by fatigue and widespread
musculoskeletal pain, tiredness, and sleep disturbances,
without any other objective findings on examination.
Interestingly, some of the clinical features of FM resemble
the ones described in the adult GH-deficiency syndrome.
Furthermore, insulin-like growth factor (IGF)-1 levels are
frequently reduced in patients with FM. To gain further
insight into the mechanisms leading to dysregulation of the
GH-IGF-1 axis in these patients, we assessed 24-h spontaneous
GH secretion, GH responses to GHRH, and IGF-1 and IGF binding
protein (BP)-3 levels before and after 4 days treatment with
human (h)GH. We found that, in comparison with controls,
patients with FM exhibited a marked decrease in spontaneous GH
secretion as assessed by mean GH secretion (2.5 +/- 0.4
microg/L in controls vs. 1.2 +/- 0.1 microg/L in FM, P <
0.05), pulse height (4.7 +/- 0.8 microg/L in controls vs. 2.5
+/- 0.3 microg/L in FM, P < 0.05), and pulse area (4.7 +/- 1
min/mg x L in controls vs. 2.3 +/- 0.3 min/mg x L in FM, P <
0.05). In contrast, GH responses to GHRH (100 microg, i.v.)
were similar in controls (mean peak, 13.5 +/- 2.5 microg/L)
and in patients with FM (12.2 +/- 3 microg/L). Finally,
treatment with hGH (2 IU, s.c. daily), over 4 days, led to a
clear-cut increase in plasma IGF-1 and IGFBP-3 levels in
patients with FM. In conclusion, our data show that patients
with FM exhibited a marked decrease in spontaneous GH
secretion, but normal pituitary responsiveness to exogenously
administered GHRH, thus suggesting the existence of an
alteration at the hypothalamic level in the neuroendocrine
control of GH in these patients. Furthermore, our finding of
increased IGF-1 and IGFBP-3 levels after GH treatment, over 4
days, opens up the possibility of testing the therapeutic
potential of hGH in patients with FM.


Leal-Cerro A, Povedano J, Astorga R, Gonzalez M, Silva H,
Garcia-Pesquera F, Casanueva FF, Dieguez C




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map