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MRI accurately depicts spread of cancer to bone

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www.ProHealth.com • September 30, 2003


OAK BROOK, Ill. – Magnetic resonance (MR) imaging is extremely accurate in helping radiologists identify involvement of soft-tissue sarcomas (malignant tumors found in connective tissue) of underlying bone, according to a study appearing in the October issue of the journal Radiology.

"Our study has shown that MR can accurately identify the presence of bone invasion in sarcoma cases," said the study's lead author, David A. Elias, M.B.B.S. "MR helps to clarify the disease stage and may help in planning surgery and making a prognosis." Dr. Elias is a former fellow in musculoskeletal radiology at the University of Toronto and a current consultant in musculoskeletal radiology at King's College Hospital NHS Trust in London, U.K.

Sarcomas are usually imaged with MR to assess soft tissue and nerve involvement for surgical planning and radiation therapy. "The purpose of our research was to investigate the accuracy of MR in determining bone involvement," said coauthor, Lawrence M. White, M.D., associate professor and head of the division of musculoskeletal imaging in the department of medical imaging at the University of Toronto.

Bone invasion by soft-tissue sarcoma is uncommon but requires bone resection. Bone invasion is associated with decreased survival and a greater proportion of high-grade versus low-grade soft-tissue sarcomas.

The researchers compared MR scans with actual surgical findings for 51 sarcoma patients to evaluate the overall accuracy of MR imaging in detecting bone invasion from soft-tissue sarcoma and found that the overall MR accuracy had 100 percent sensitivity and 93 percent specificity. In addition, MR displayed a 79 percent positive predictive value and 100 percent negative predictive value.

"This research gives radiologists the confidence to say they believe the MR results are accurate when evaluating sarcoma's bone involvement," Dr. White said. "In the past, this confidence was reserved for soft-tissue involvement."


Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Virginia. Radiology is owned and published by the Radiological Society of North America Inc. (http://radiology.rsnajnls.org).

The Radiological Society of North America (RSNA) is an association of more than 33,000 radiologists, radiation oncologists and related scientists committed to promoting excellence through education and by fostering research, with the ultimate goal of improving patient care. The Society's headquarters are located at 820 Jorie Boulevard, Oak Brook, Ill. 60523-2251. (http://www.rsna.org).

"Osseous Invasion by Soft-Tissue Sarcoma: Assessment with MR Imaging." Collaborating with Drs. Elias and White on this study were David J. Simpson, M.B.B.S., Rita A. Kandel, M.D., George Tomlinson, Ph.D., Robert S. Bell, M.D., and Jay S. Wunder, M.D.

Source: www.eurekalert.org



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