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Hormonal pertubations in fibromyalgia (FM) syndrome

  [ 131 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 22, 1999


The symptomatology characterizing fibromyalgia (FM) comprises three
systems: the musculoskeletal system with widespread muscular
pain, neuroendocrine disorders, and psychological distress
including depression. Though the most prominent symptom of FM
is pain in defined points of the musculoskeletal system, the
numerous other somatoform and psychological disorders suppose
a common primary disturbance which we consider to originate
within higher levels of the central nervous system.

Recent
studies of the entire endocrine profile of FM patients
following a simultaneous challenge of the hypophysis with
corticotropin-releasing hormone (CRH), thyrotropin-releasing
hormone, growth hormone-releasing hormone, and luteinizing
hormone-releasing hormone support the hypothesis that an
elevated activity of CRH neurons determines not only many
symptoms of FM but may also cause the deviations observed in
the other hormonal axes. Hypothalamic CRH neurons thus may
play a key role not only in "resetting" the various endocrine
loops but possibly also nociceptive and psychological
mechanisms as well.

Neeck G, Riedel W




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