ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

 
Print Page
Email Article

Antidepressant therapy for unexplained symptoms & symptom syndromes - fibromyalgia and Chronic Fatigue Syndrome related research

  [ 43 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 15, 1999


OBJECTIVE: To determine the efficacy of antidepressant therapy for
unexplained symptoms or symptom syndromes.

SEARCH STRATEGIES:
We identified original studies through searching MEDLINE,
EMBASE, PsycLIT, the Federal Research in Progress database,
and The Cochrane Library. We also searched the bibliographies
of primary and review articles for additional studies.

SELECTION CRITERIA: We excluded trials of patients with
neuropathic, oncologic, or degenerative joint pain.
Independent duplicate review of 392 articles identified 94
relevant reports of randomized trials involving 6595 patients
across 6 symptom syndromes. Independent duplicate assessment
was made for inclusion and data abstraction. Meta-analysis was
performed on extractable placebo-controlled data. MAIN

RESULTS: Of 94 included trials, most studied either tricyclic
antidepressants, antiserotonin antidepressants, selective
serotonin reuptake inhibitors (SSRIs), or multiple agents for
the treatment of the following syndromes: headache (50),
fibromyalgia (18), functional gastrointestinal syndromes (13),
idiopathic pain (11), tinnitus (2), and chronic fatigue (2).

The quality of the studies was fair (mean score = 4.8 on a
scale of 0 to 8). A majority of the studies (69%) demonstrated
benefit for at least one outcome measure. Symptom improvement
typically did not correlate with depression response in the
few studies where it was assessed. Meta-analysis of all
extractable data showed a substantial benefit from
antidepressants: For the dichotomous outcome of improvement,
the odds ratio was 3.4 (95% confidence interval [CI], 2.6 -
4.5), and for continuous outcomes, the standardized mean
difference was 0.87 (95% CI, 0.59-1.14). The absolute
percentage difference in improvement between the
antidepressant and placebo arms was 32%, yielding a number
needed to treat of 3 to improve one person's symptoms.

Meta-regression indicated no differential effect across the
classes of antidepressants; however, onbivariate tally
tricyclic studies were associated with a greater likelihood of
efficacy than SSRI studies (P = .02).

CONCLUSIONS:
Antidepressants can be effective for various physical symptoms
and symptom syndromes. The relation of outcome to depression
and the efficacy of SSRIs needs further study.

O'Malley PG, Jackson JL, Santoro J, Tomkins G, Balden E, Kroenke K




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Breaking Through the Mental Fog Breaking Through the Mental Fog
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map