ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Antidepressant therapy for unexplained symptoms & symptom syndromes - fibromyalgia and Chronic Fatigue Syndrome related research

  [ 43 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 15, 1999


OBJECTIVE: To determine the efficacy of antidepressant therapy for
unexplained symptoms or symptom syndromes.

SEARCH STRATEGIES:
We identified original studies through searching MEDLINE,
EMBASE, PsycLIT, the Federal Research in Progress database,
and The Cochrane Library. We also searched the bibliographies
of primary and review articles for additional studies.

SELECTION CRITERIA: We excluded trials of patients with
neuropathic, oncologic, or degenerative joint pain.
Independent duplicate review of 392 articles identified 94
relevant reports of randomized trials involving 6595 patients
across 6 symptom syndromes. Independent duplicate assessment
was made for inclusion and data abstraction. Meta-analysis was
performed on extractable placebo-controlled data. MAIN

RESULTS: Of 94 included trials, most studied either tricyclic
antidepressants, antiserotonin antidepressants, selective
serotonin reuptake inhibitors (SSRIs), or multiple agents for
the treatment of the following syndromes: headache (50),
fibromyalgia (18), functional gastrointestinal syndromes (13),
idiopathic pain (11), tinnitus (2), and chronic fatigue (2).

The quality of the studies was fair (mean score = 4.8 on a
scale of 0 to 8). A majority of the studies (69%) demonstrated
benefit for at least one outcome measure. Symptom improvement
typically did not correlate with depression response in the
few studies where it was assessed. Meta-analysis of all
extractable data showed a substantial benefit from
antidepressants: For the dichotomous outcome of improvement,
the odds ratio was 3.4 (95% confidence interval [CI], 2.6 -
4.5), and for continuous outcomes, the standardized mean
difference was 0.87 (95% CI, 0.59-1.14). The absolute
percentage difference in improvement between the
antidepressant and placebo arms was 32%, yielding a number
needed to treat of 3 to improve one person's symptoms.

Meta-regression indicated no differential effect across the
classes of antidepressants; however, onbivariate tally
tricyclic studies were associated with a greater likelihood of
efficacy than SSRI studies (P = .02).

CONCLUSIONS:
Antidepressants can be effective for various physical symptoms
and symptom syndromes. The relation of outcome to depression
and the efficacy of SSRIs needs further study.

O'Malley PG, Jackson JL, Santoro J, Tomkins G, Balden E, Kroenke K




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map