Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Best Herbs to Help With Insomnia

 
Print Page
Email Article

Four Patients in Clinical Trial Ill after Medicating with Promising Alzheimer’s Vaccine

  [ 42 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 28, 2002




The promising Alzheimer vaccine AN-1792, which showed impressive clinical results as a treatment for mild to moderate Alzheimer's disease last summer, has suffered a setback in the current Phase 2A clinical trial.

The Elan corporation and Wyeth-Ayerst Laboratories have decided to temporarily suspend dosing in this Phase 2A study after four patients in France were reported to have clinical signs consistent with inflammation in the central nervous system. All four patients are receiving appropriate medical care and the companies are working with clinical investigators to determine the cause of this development.

"The well-being of patients is always our paramount concern. Our decision to temporarily suspend further dosing, pending the results of our evaluation, is a standard approach to protect the safety of patients in clinical trials," stated Dr. Ivan Lieberburg, Elan's Chief Scientific and Medical Officer. "A decision will be made on resumption of dosing pending the outcome of this investigation."

There are many agents and mechanisms that can result in inflammation of the central nervous system, one being a viral infection. The presence of virus within the cerebrospinal fluid was reported in some of the four patients under investigation. However, the cause of the inflammation remains to be determined.

To date, approximately 360 patients have received multiple doses of AN-1792. In the Phase 2A study, 97 patients in France have received the drug.

The study is still ongoing however, and the dosing schedule should provide time for the clinical investigation to occur without jeopardizing study conduct.

In Phase 1 safety studies, AN-1792 was administered to more than 80 patients with mild to moderate Alzheimer's disease in a variety of dosage regimens. The results from the U.S. single dose trial, and the U.K. multiple dose trial indicated that AN-1792 was well tolerated and that a proportion of patients developed an appropriate immunological response to AN-1792.

The Phase 2A study was designed to measure the immune response to beta amyloid peptide immunization in patients with Alzheimer's disease. Patients with mild to moderate Alzheimer's disease were enrolled and evaluated using conventional cognitive tests and by other surrogate measures.

The results of this study are expected to provide additional information regarding the immune response to AN-1792, as well as valuable information useful for the development of other therapeutic agents being studied as part of the collaborative development program.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map