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The responsiveness of generic quality of life instruments in rheumatic diseases. A systematic review of randomized controlled trials - fibromyalgia related research

  [ 73 votes ]   [ Discuss This Article ] • January 5, 1999

To review the available evidence that has used generic
instruments alone or in comparison with disease specific
instruments. A systematic review was carried out using the
methods recommended by the Cochrane Collaboration. We used
MEDLINE and EMBASE searches and we performed a hand search of
the abstracts listed under "quality of life" at American
College of Rheumatology (ACR) meetings. Selection was limited
to randomized controlled trials (RCT) using generic
instruments in populations older than 18 years with any of the
following diseases: rheumatoid arthritis, fibromyalgia,
osteoporosis, osteoarthritis, systemic lupus erythematosus,
and ankylosing spondylitis.

Language was restricted to English
papers. Studies using only disease-specific instruments were
excluded. From 488 articles retrieved, 13 reports of 10
randomized controlled trials were selected. There were 101
abstracts on quality of life in ACR abstract books; 78
abstracts contained data on generic instruments, and of these,
9 described their use in RCT. Despite a substantial increase
in the number of papers and abstracts addressing different
aspects of generic questionnaires, the majority of the papers
were descriptive.

The evidence is not yet available to
document that any of the generic instruments pass the
requirements of the OMERACT Filter.

Ortiz Z, Shea B, Garcia Dieguez M, Boers M, Tugwell P, Boonen A,
Wells G

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