ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

E. coli Bacteria Make Alzheimer's-linked Fibers

  [ 8 votes ]   [ Discuss This Article ] • February 8, 2002

New research from the Washington University School of Medicine in St. Louis has shown fibers known to be important in Alzheimer's disease are also produced by bacteria that cause ailments and infections. The finding are published in the February 1 issue of the journal Science.

The scientists found that certain strains of the bacterium Escherichia coli (E. coli) produce amyloid fibers similar to those that can accumulate in the brain to form plaque, a hallmark of Alzheimer's disease. The bacterial fibers, known as curli, form a meshwork around the bacteria, joining them together in clusters or communities known as biofilms. Bacteria in biofilms are more resistant to antibiotics and to the body's immune defenses.

The discovery marks the first time that amyloid has been found in bacteria. Previously, amyloid was thought to be made only by cells of higher organisms. Even then, their presence was regarded as a mistake, a biological error.

"This is the first example of a dedicated molecular machinery to produce amyloid and thus shows that amyloid production is not always a mistake," says Scott J. Hultgren, Ph.D., the Helen Lehbrink Stoever Professor of Molecular Microbiology, and leader of the study. "This finding gives us a powerful genetic system to study the molecular details of amyloid formation and may allow us to begin designing drugs that will block the formation of amyloid or treat or prevent human amyloid diseases."

The finding also raises the important question of whether bacterial infections play some role in amyloid diseases, including Alzheimer's disease. Human amyloid diseases are also thought to involve dissolved amyloid proteins that undergo a change in shape and aggregate into fibers, Hultgren said. When those fibers develop in the brain, it leads to Alzheimer's disease.

"Bacteria might contribute directly to plaque formation through the amyloid they produce," said Matthew R. Chapman, Ph.D., post-doctoral fellow in molecular microbiology and first author, "or they might contribute indirectly by triggering the precipitation of amyloid precursor proteins already present in the body."

"Learning that bacteria produce amyloid is a revelation," said Paul Berg, Cahill Professor of Cancer Research and Biochemistry, Emeritus, at Stanford University School of Medicine and winner of the 1980 Nobel Prize in Chemistry. "That discovery provides an additional vantage point from which to assess the role of amyloid production and accumulation in Alzheimer's disease and related neuro-pathologies. Hopefully, this model will reveal clues for preventing the devastating formation of amyloid plaques characteristic of those diseases."

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map