ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Discovery of Critical DNA-Repair Enzyme Helps Researchers Understand Alzheimer’s, Aging, Cancer

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 25, 2002


Using data from the Human Genome Project, researchers have identified a key part of the toolkit human cells use to repair damage to their genetic material, damage that has been implicated in everything from Alzheimer's disease to cancer to the normal aging process.

In a paper published in the March issue of Proceedings of the National Academy of Sciences, researchers describe their discovery and characterization of an enzyme that works to fix errors introduced into human DNA by oxidative stress, one of the most common processes operating on living cells.

Oxidative damage to DNA occurs when the chemical bases that spell out the genetic code are attacked by highly reactive oxygen, substances produced naturally as a byproduct of respiration and also as a result of infection, inflammation, cigarette smoking and alcohol consumption. Unless they are corrected, the resulting changes are then passed along to the cell's descendants, causing a dangerous accumulation of genetic mistakes.

"Oxidative damage is the mother of all damage," says Mitra, a professor in Sealy Center for Molecular Science of the University of Texas Medical Branch at Galveston. "It is the dominant form of stress in aerobic organisms, and we are constantly experiencing it -- every time we breathe we are exposed to oxidative stress. So our DNA has to have a repair mechanism."

To better understand how the repair mechanism functions, Mitra and his colleagues decided to find sequences in the human genome database for DNA repair enzymes similar to those identified as glycosylases in the bacteria E. coli.

After identifying two such sequences, the researchers used one of them to produce a previously unknown protein, which proved able to function as a glycosylase when tested on damaged DNA. This glycosylase, which they named NEH1, is the first to be discovered in a new class of mammalian DNA repair enzymes, and it possesses two characteristics that make it seem a particularly important player in the struggle against oxidative damage.

First, unlike the other mammalian glycosylases, NEH1 may work on the small, critical portion of human DNA that is actually active. (Only 3 percent of the total genome carries functional genetic information, and based on current evidence it appears likely that the other DNA glycosylases operate only on inactive DNA.) Second, cells produce far more NEH1 when their DNA is replicating -- as if in an effort to catch any errors introduced by oxidative stress before they are passed on to the next generation.

The researchers also examined human tissues for NEH1, seeking to determine its relative level in different organs of the body. They found that messenger RNA coding for NEH1 was highest in the liver, pancreas and thymus.

According to Mitra, the identification of NEH1 is a crucial step toward working out the ways in which oxidative stress produces any number of health problems. "What we are seeing are the subtle nuances of repair," Mitra says. Knowledge of how the DNA repair process works in different people -- how it can vary depending on age, genetic heritage and exposure to toxins and pathogens -- could be highly useful in understanding individual susceptibility to disease. Understanding how it functions differently in different organs of the body -- NEH1's high levels in the liver are especially intriguing, for example -- may shed light on disorders of particular human systems.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3 Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map