ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Astaxanthin Is a Longevity Promoter

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

 
Print Page
Email Article

Researchers Find How Alzheimer's Kills Nerve Cells, Develop New Drugs

  [ Not Yet Rated ]   [ Discuss This Article ]
www.ProHealth.com • May 1, 2002


Gerontologists at the University of Southern California have discovered how the chief molecular villain of Alzheimer's disease kills nerve cells - and have identified two drugs that appear to cancel its toxicity.

The finding, reported in the May 1 issue of the Journal of Neuroscience, is apparently a solid advance in the quest to cure the degenerative brain disease that afflicts roughly 4 million Americans and kills about 100,000 each year.

The harmful molecule - called the beta-amyloid peptide - has long been associated with the progressive, mind-eroding cell die-offs that AD patients suffer. But the causal chain has been indirect and the list of suspects long.

Instead of directly affecting neurons, the brain's computing cells, the beta-amyloid stimulates a different kind of brain cell called microglia to release peroxynitrite - a brain toxin.

Microglia act like janitors, mopping up substances that don't belong in the brain. However, when the microglia come into contact with beta-amyloid, their response is to release a neurotoxin, which is disastrous for the system they are designed to maintain.

Valter Longo, an assistant professor of gerontology at USC's Leonard Davis School of Gerontology, led the research team that finally identified beta-amyloid's modus operandi and its accomplices.

"It was a tricky experiment to perform," said Longo, who holds the Paul F. Glenn Foundation Chair in Cellular and Molecular Biology, "because peroxynitrite is a very short-lived molecule and is very difficult to measure. (But) peroxynitrite appears by far to be the most toxic molecule that is produced in response to beta-amyloid."

But there is a silver lining: The researchers also identified two drugs that may effectively block peroxynitrite's toxicity. The next stage of research will be to test these drugs on mice that have been bred to acquire a rodent version of AD, said Longo. If either of the drugs proves safe and effective for the mice, human clinical trials may follow.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map